Severe covid-19 pneumonia has posed critical challenges for the research and medical
communities. Older age, male sex, and comorbidities increase the risk for severe disease …

The novel coronavirus disease 2019 (COVID-19) pandemic is a global crisis, challenging
healthcare systems worldwide. Many patients present with a remarkable disconnect in rest …

Rationale: Coronavirus disease (COVID-19) is a global threat to health. Its inflammatory
characteristics are incompletely understood. Objectives: To define the cytokine profile of …

Abstract Background Currently, the United States has the largest number of reported
coronavirus disease 2019 (COVID-19) cases and deaths globally. Using a geographically …

The COVID-19 pandemic has seen a surge of patients with acute respiratory distress
syndrome (ARDS) in intensive care units across the globe. As experience of managing …

Rationale: Initial reports of case fatality rates (CFRs) among adults with coronavirus disease
(COVID-19) receiving invasive mechanical ventilation (IMV) are highly variable. Objectives …

Purpose The main characteristics of mechanically ventilated ARDS patients affected with
COVID-19, and the adherence to lung-protective ventilation strategies are not well known …

Background In the current SARS-CoV-2 pandemic, there has been worldwide debate on the
use of corticosteroids in COVID-19. In the recent RECOVERY trial, evaluating the effect of …

Introduction Coronavirus disease of 2019 (COVID-19) has resulted in millions of cases
worldwide. As the pandemic has progressed, the understanding of this disease has evolved …

Although critical illness has been associated with SARS-CoV-2–induced hyperinflammation,
the immune correlates of severe COVID-19 remain unclear. Here, we comprehensively …