Olfactory immune response to SARS-CoV-2

SA Wellford, EA Moseman - Cellular & Molecular Immunology, 2024 - nature.com
Numerous pathogens can infect the olfactory tract, yet the pandemic caused by SARS-CoV-
2 has strongly emphasized the importance of the olfactory mucosa as an immune barrier …

Gut as an alternative entry route for SARS-CoV-2: current evidence and uncertainties of productive enteric infection in COVID-19

LA Clerbaux, SA Mayasich, A Muñoz, H Soares… - Journal of clinical …, 2022 - mdpi.com
The gut has been proposed as a potential alternative entry route for SARS-CoV-2. This was
mainly based on the high levels of SARS-CoV-2 receptor expressed in the gastrointestinal …

Modulation of type I interferon responses potently inhibits SARS-CoV-2 replication and inflammation in rhesus macaques

EG Viox, TN Hoang, AA Upadhyay, R Nchioua… - Science …, 2023 - science.org
Type I interferons (IFN-I) are critical mediators of innate control of viral infections but also
drive the recruitment of inflammatory cells to sites of infection, a key feature of severe …

Adaptive immune cells are necessary for SARS-CoV-2–induced pathology

B Imbiakha, JM Sahler, DW Buchholz, S Ezzatpour… - Science …, 2024 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is causing the ongoing
global pandemic associated with morbidity and mortality in humans. Although disease …

Nucleocapsid-specific T cell responses associate with control of SARS-CoV-2 in the upper airways before seroconversion

TM Eser, O Baranov, M Huth, MIM Ahmed… - Nature …, 2023 - nature.com
Despite intensive research since the emergence of SARS-CoV-2, it has remained unclear
precisely which components of the early immune response protect against the development …

Intranasal pediatric parainfluenza virus-vectored SARS-CoV-2 vaccine is protective in monkeys

C Le Nouën, CE Nelson, X Liu, HS Park, Y Matsuoka… - Cell, 2022 - cell.com
Pediatric SARS-CoV-2 vaccines are needed that elicit immunity directly in the airways as
well as systemically. Building on pediatric parainfluenza virus vaccines in clinical …

Co-infection of mice with SARS-CoV-2 and Mycobacterium tuberculosis limits early viral replication but does not affect mycobacterial loads

PJ Baker, EP Amaral, E Castro, AC Bohrer… - Frontiers in …, 2023 - frontiersin.org
Viral co-infections have been implicated in worsening tuberculosis (TB) and during the
COVID-19 pandemic, the global rate of TB-related deaths has increased for the first time in …

DYRK1A promotes viral entry of highly pathogenic human coronaviruses in a kinase-independent manner

MS Strine, WL Cai, J Wei, MM Alfajaro, RB Filler… - PLoS …, 2023 - journals.plos.org
Identifying host genes essential for Severe Acute Respiratory Syndrome Coronavirus 2
(SARS-CoV-2) has the potential to reveal novel drug targets and further our understanding …

[HTML][HTML] Single-nucleus transcriptomic profiling of multiple organs in a rhesus macaque model of SARS-CoV-2 infection

Q Ma, W Ma, TZ Song, Z Wu, Z Liu, Z Hu… - Zoological …, 2022 - ncbi.nlm.nih.gov
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes
diverse clinical manifestations and tissue injuries in multiple organs. However, cellular and …

Anti-MDA5 antibody linking COVID-19, type I interferon, and autoimmunity: a case report and systematic literature review

A Tonutti, F Motta, A Ceribelli, N Isailovic… - Frontiers in …, 2022 - frontiersin.org
Introduction The SARS-CoV-2 infection has been advocated as an environmental trigger for
autoimmune diseases, and a paradigmatic example comes from similarities between COVID …