The Y chromosome: a blueprint for men's health?
AA Maan, J Eales, A Akbarov, J Rowland… - European Journal of …, 2017 - nature.com
The Y chromosome has long been considered a 'genetic wasteland'on a trajectory to
completely disappear from the human genome. The perception of its physiological function …
completely disappear from the human genome. The perception of its physiological function …
Y chromosome, hypertension and cardiovascular disease: is inflammation the answer?
SI Khan, KL Andrews, GL Jennings… - International journal of …, 2019 - mdpi.com
It is now becomingly increasingly evident that the functions of the mammalian Y
chromosome are not circumscribed to the induction of male sex. While animal studies have …
chromosome are not circumscribed to the induction of male sex. While animal studies have …
[HTML][HTML] A genomic atlas of human adrenal and gonad development
I Del Valle, F Buonocore, AJ Duncan, L Lin… - Wellcome open …, 2017 - ncbi.nlm.nih.gov
Background: In humans, the adrenal glands and gonads undergo distinct biological events
between 6-10 weeks post conception (wpc), such as testis determination, the onset of …
between 6-10 weeks post conception (wpc), such as testis determination, the onset of …
SARS-CoV-2 infection: molecular mechanisms of severe outcomes to suggest therapeutics
N Hartog, W Faber, A Frisch, J Bauss… - Expert review of …, 2021 - Taylor & Francis
Introduction: The year 2020 was defined by the 29,903 base pairs of RNA that codes for the
SARS-CoV-2 genome. SARS-CoV-2 infects humans to cause COVID-19, spreading from …
SARS-CoV-2 genome. SARS-CoV-2 infects humans to cause COVID-19, spreading from …
Chromosome Y genetic variants: impact in animal models and on human disease
JW Prokop, CF Deschepper - Physiological genomics, 2015 - journals.physiology.org
Chromosome Y (chrY) variation has been associated with many complex diseases ranging
from cancer to cardiovascular disorders. Functional roles of chrY genes outside of testes are …
from cancer to cardiovascular disorders. Functional roles of chrY genes outside of testes are …
Similarities and differences of X and Y chromosome homologous genes, SRY and SOX3, in regulating the renin-angiotensin system promoters
FC Araujo, A Milsted, IKM Watanabe… - Physiological …, 2015 - journals.physiology.org
The renin-angiotensin system (RAS) is subject to sex-specific modulation by hormones and
gene products. However, sex differences in the balance between the vasoconstrictor …
gene products. However, sex differences in the balance between the vasoconstrictor …
Aging-and gender-related modulation of RAAS: potential implications in COVID-19 disease
L Monteonofrio, MC Florio, M AlGhatrif… - Vascular …, 2021 - vb.bioscientifica.com
Coronavirus disease 2019 (COVID-19) is a new infectious disease caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is frequently characterized by …
respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is frequently characterized by …
Transcriptional analysis of the multiple Sry genes and developmental program at the onset of testis differentiation in the rat
JW Prokop, SB Chhetri, JE van Veen, X Chen… - Biology of sex …, 2020 - Springer
Background The commonly used laboratory rat, Rattus norvegicus, is unique in having
multiple Sry gene copies found on the Y chromosome, with different copies encoding amino …
multiple Sry gene copies found on the Y chromosome, with different copies encoding amino …
Analysis of Sry duplications on the Rattus norvegicus Y-chromosome
JW Prokop, AC Underwood, ME Turner, N Miller… - BMC genomics, 2013 - Springer
Background Gene copy number variation plays a large role in the evolution of genomes. In
Rattus norvegicus and other rodent species, the Y-chromosome has accumulated multiple …
Rattus norvegicus and other rodent species, the Y-chromosome has accumulated multiple …
The phenotypic impact of the male-specific region of chromosome-Y in inbred mating: the role of genetic variants and gene duplications in multiple inbred rat strains
JW Prokop, SW Tsaih, AB Faber, S Boehme… - Biology of sex …, 2016 - Springer
Backgound The male-specific region of chromosome-Y (MSY) contributes to phenotypes
outside of testis development and has a high rate of evolution between mammalian species …
outside of testis development and has a high rate of evolution between mammalian species …