Lysosomes are membrane-bound organelles with roles in processes involved in degrading
and recycling cellular waste, cellular signalling and energy metabolism. Defects in genes …

Amongst the lysosomal cysteine cathepsin family of proteases, cathepsin S (CTSS) holds
particular interest due to distinctive properties including a normal restricted expression …

The eye is a sensory organ exposed to the environment and protected by a mucosal tissue
barrier. While it shares a number of features with other mucosal tissues, the ocular mucosal …

Primary Sjögren syndrome is an autoimmune disease that mainly affects exocrine glands
such as the salivary and lacrimal glands. In addition, systemic involvement is common …

Abstract CD25 knock-out (CD25KO) mice spontaneously develop Sjögren Syndrome (SS)-
like inflammation. We investigated the role of commensal bacteria by comparing CD25KO …

Sjögren's syndrome (SS) is a chronic, progressive, inflammatory, autoimmune disease,
characterized by the lymphocyte infiltration of exocrine glands, especially the lacrimal and …

Cathepsin S (Ctss) is a protease that is proinflammatory on epithelial cells. The purpose of
this study was to investigate the role of Ctss in age-related dry eye disease. Ctss−/− mice [in …

Background Antibody-mediated rejection (AMR) accounts for> 50% of kidney allograft loss.
Donor-specific antibodies (DSA) against HLA and non-HLA antigens in the glomeruli and …

Various cytokines, including interferon (IFN)-γ and IL-17, are augmented, and autoreactive T
cells and B cells are activated in the immune pathogenesis of Sjögren's syndrome (SS). In …

Cathepsin S (CTSS) is highly increased in Sjögren's syndrome (SS) patients tears and in
tears and lacrimal glands (LG) of male non-obese diabetic (NOD) mice, a murine model of …