Type II diabetes mellitus and its related complications are growing public health problems.
Many natural products present in our diet, including polyphenols, can be used in treating …

One of the greatest examples of integrated signal transduction is revealed by examination of
effects mediated by AKT kinase in myocardial biology. Positioned at the intersection of …

Diabetes increases the risk of cardiovascular diseases. Berberine (BBR), an isoquinoline
alkaloid used in Chinese medicine, exerts anti-diabetic effect by lowering blood glucose and …

Danshensu, as the effective component of Salvia miltiorrhiza (Danshen), has been widely
used in clinic for treatment of cardiovascular diseases in China. In the present study, we …

Background microRNAs (miRNAs) are a class of small, non-coding endogenous RNAs that
post-transcriptionally regulate some protein-coding genes. miRNAs play an important role in …

Adrenomedullin 2 (AM2) or intermedin is a member of the calcitonin gene‐related peptide
(CGRP)/calcitonin family of peptides and was discovered in 2004. Unlike other members of …

Pharmacological blockade of the ANG II type 1 receptor (AT1R) is a common therapy for
treatment of congestive heart failure and hypertension. Increasing evidence suggests that …

Myocardial dysfunction is an important manifestation of sepsis. Previous studies suggest that
melatonin is protective against sepsis. In addition, activation of the phosphatidylinositol 3 …

Berberine (BBR) confers cardioprotective effect against myocardial ischemia reperfusion
injury (MI/RI). Activation of Notch1/Hairy and enhancer of split 1 (Hes1) signaling also …

Background The present study was to investigate the effects and mechanism of Luteolin on
myocardial infarct size, cardiac function and cardiomyocyte apoptosis in diabetic rats with …