Cognitive impairment in schizophrenia: aetiology, pathophysiology, and treatment

RA McCutcheon, RSE Keefe, PK McGuire - Molecular psychiatry, 2023 - nature.com
Cognitive deficits are a core feature of schizophrenia, account for much of the impaired
functioning associated with the disorder and are not responsive to existing treatments. In this …

Antipsychotic dose, dopamine D2 receptor occupancy and extrapyramidal side-effects: a systematic review and dose-response meta-analysis

S Siafis, H Wu, D Wang, A Burschinski, N Nomura… - Molecular …, 2023 - nature.com
Antipsychotic drugs differ in their propensity to cause extrapyramidal side-effects (EPS), but
their dose-effects are unclear. Therefore, we conducted a systematic review and dose …

European Psychiatric Association guidance on assessment of cognitive impairment in schizophrenia

A Vita, W Gaebel, A Mucci, G Sachs, A Erfurth… - European …, 2022 - cambridge.org
Background Impairment in a wide range of cognitive abilities has been consistently reported
in individuals with schizophrenia. Both neurocognitive and social cognitive deficits are …

[HTML][HTML] Cognitive dysfunction in schizophrenia: an expert group paper on the current state of the art

PD Harvey, M Bosia, R Cavallaro, OD Howes… - Schizophrenia Research …, 2022 - Elsevier
Cognitive impairment in schizophrenia represents one of the main obstacles to clinical and
functional recovery. This expert group paper brings together experts in schizophrenia …

Cognitive impairment associated with schizophrenia: from pathophysiology to treatment

DC Javitt - Annual Review of Pharmacology and Toxicology, 2023 - annualreviews.org
Cognitive impairment is a core feature of schizophrenia and a major contributor to poor
functional outcomes. Methods for assessment of cognitive dysfunction in schizophrenia are …

Pneumonia risk, antipsychotic dosing, and anticholinergic burden in schizophrenia

JJ Luykx, CU Correll, P Manu, A Tanskanen… - JAMA …, 2024 - jamanetwork.com
Importance Antipsychotic drugs (particularly clozapine) have been associated with
pneumonia in observational studies. Despite studies of the associations between …

Safety assessment of Brexpiprazole: real-world adverse event analysis from the FAERS database

Y Jiang, L Zhou, Y Shen, Q Zhou, Y Ji, H Zhu - Journal of Affective …, 2024 - Elsevier
Objective This study aims to analysis adverse drug events (ADE) related to Brexpiprazole
from the third quarter of 2015 to the first quarter of 2023 from FAERS database. Methods The …

Psychosis spectrum illnesses as disorders of prefrontal critical period plasticity

S Vinogradov, MV Chafee, E Lee… - …, 2023 - nature.com
Emerging research on neuroplasticity processes in psychosis spectrum illnesses—from the
synaptic to the macrocircuit levels—fill key gaps in our models of pathophysiology and open …

Effects of antipsychotic and anticholinergic medications on cognition in chronic patients with schizophrenia

C Haddad, P Salameh, H Sacre, JP Clément, B Calvet - BMC psychiatry, 2023 - Springer
Background Patients with psychosis frequently use a variety of psychotropic medicines,
many of which have anticholinergic effects that can impair cognition. Therefore, this study …

Cognitive trajectories following onset of psychosis: a meta-analysis

AJ Watson, L Harrison, A Preti, T Wykes… - The British Journal of …, 2022 - cambridge.org
Background Cognitive impairment is a core feature of schizophrenia, associated with poor
functional outcomes. The course of cognitive function in the years following illness onset has …