Progressive pulmonary fibrosis (PF) is a complex interstitial lung disease that impacts
substantially on patients' daily lives, requiring personalised and integrated care. We …

SUMMARY OF KEY POINTS International respiratory organizations now recommend using
lower limit of normal and standardized residuals to diagnose airflow obstruction and COPD …

Rationale: Cardiopulmonary exercise testing (CPET) is the gold standard to evaluate
exertional breathlessness, a common and disabling symptom. However, the interpretation of …

Background: Opioids are recommended to treat advanced refractory dyspnoea despite
optimal therapy by the American Thoracic Society clinical practice guidelines, while newly …

Breathlessness is a centrally processed symptom, as evidenced by activation of distinct
brain regions such as the insular cortex and amygdala, during the anticipation and/or …

Should opioids be used for breathlessness and in whom? A PRO... : Current Opinion in
Supportive and Palliative Care Should opioids be used for breathlessness and in whom? A …

In the older adult with a serious illness, the goal of palliative medicine, especially when
focusing on symptom management, is to optimize quality of life. As we discuss pain …

Objective: To determine the prevalence of clinical significance reporting in contemporary
comparative effectiveness research (CER). Background: In CER, a statistically significant …

Background Exertional breathlessness is a major symptom in cardiorespiratory disease and
is often assessed using the modified Medical Research Council (mMRC) questionnaire. The …

Abstract Background and Objective Preference-based outcome measures are commonly
applied in economic analyses to inform healthcare resource allocation decisions. Few …