PARPs and tankyrases (TNKS) represent a family of 17 proteins. PARPs and tankyrases
were originally identified as DNA repair factors, nevertheless, recent advances have shed …

Liver disease encompasses pathologies as non-alcoholic fatty liver disease, non-alcoholic
steatohepatitis, alcohol liver disease, hepatocellular carcinoma, viral hepatitis, and …

Nonalcoholic steatohepatitis (NASH) prevalence is rising with no pharmacotherapy
approved. A major hurdle in NASH drug development is the poor translatability of preclinical …

Recent studies suggest that exercise alters the gut microbiome. We determined whether six-
weeks endurance exercise, without changing diet, affected the gut metagenome and …

The gut microbiome is emerging as an important factor in regulating mental health yet it
remains unclear what the target should be for psychiatric treatment. We aimed to elucidate …

Background & Aims The prevalence of nonalcoholic fatty liver disease (NAFLD) has
increased with the obesity pandemic. We analyzed the transcriptional profiles of …

Faecalibacterium prausnitzii is considered as one of the most important bacterial indicators
of a healthy gut. We studied the effects of oral F. prausnitzii treatment on high-fat fed mice …

Background and Purpose The gut–liver axis is associated with the progression of non‐
alcoholic fatty liver disease (NAFLD). Targeting the gut–liver axis and bile acid‐based …

Hepatocellular carcinoma (HCC) ranks number three among the most frequent causes of
death from solid tumors worldwide. With obesity and fatty liver diseases as risk factors on the …

Non-Alcoholic Fatty Liver Disease (NAFLD) is the most common liver disease in the world.
NAFLD is principally characterized by an excessive fat accumulation in the hepatocytes. Diet …