Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …

Obesity remains the most important risk factor for the incidence and progression of
osteoarthritis (OA). The leading cause of OA was believed to be overloading the joints due to …

Besides its role as an energy storage organ, adipose tissue can be viewed as a dynamic
and complex endocrine organ, which produces and secretes several adipokines, including …

SARS-COV-2 virus is responsible for the ongoing devastating pandemic. Since the early
phase of the pandemic, the “cytokine-storm” appeared a peculiar aspect of SARS-COV-2 …

Mesenchymal stem cell (MSC) therapies have been used as cell-based treatments for
decades, owing to their anti-inflammatory, immunomodulatory, and regenerative properties …

Osteoarthritis (OA), the leading cause of pain and disability worldwide, disproportionally
affects individuals with obesity. The mechanisms by which obesity leads to the onset and …

Collagens serve essential mechanical functions throughout the body, particularly in the
connective tissues. In articular cartilage, collagens provide most of the biomechanical …

Knee osteoarthritis (KOA) is the most common form of joint degeneration with increasing
prevalence and incidence in recent decades. KOA is a molecular disorder characterized by …

Obesity reaches up to epidemic proportions globally and increases the risk for a wide
spectrum of co-morbidities, including type-2 diabetes mellitus (T2DM), hypertension …

The rising prevalence of osteoarthritis (OA) in the general population has necessitated the
development of novel treatment options. It is critical to recognize the joint as a separate …