Mechanisms of synaptic transmission dysregulation in the prefrontal cortex: pathophysiological implications

Z Yan, B Rein - Molecular psychiatry, 2022 - nature.com
The prefrontal cortex (PFC) serves as the chief executive officer of the brain, controlling the
highest level cognitive and emotional processes. Its local circuits among glutamatergic …

Circuit organization of the rodent medial prefrontal cortex

PG Anastasiades, AG Carter - Trends in neurosciences, 2021 - cell.com
The prefrontal cortex (PFC) orchestrates higher brain function and becomes disrupted in
many mental health disorders. The rodent medial PFC (mPFC) possesses an enormous …

Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction

DA Nation, MD Sweeney, A Montagne, AP Sagare… - Nature medicine, 2019 - nature.com
Vascular contributions to cognitive impairment are increasingly recognized,,,–as shown by
neuropathological,, neuroimaging,,,–, and cerebrospinal fluid biomarker, studies. Moreover …

[PDF][PDF] Multi-sensory gamma stimulation ameliorates Alzheimer's-associated pathology and improves cognition

AJ Martorell, AL Paulson, HJ Suk, F Abdurrob… - Cell, 2019 - cell.com
We previously reported that inducing gamma oscillations with a non-invasive light flicker
(gamma entrainment using sensory stimulus or GENUS) impacted pathology in the visual …

The role of the medial prefrontal cortex in cognition, ageing and dementia

DD Jobson, Y Hase, AN Clarkson… - Brain …, 2021 - academic.oup.com
Humans require a plethora of higher cognitive skills to perform executive functions, such as
reasoning, planning, language and social interactions, which are regulated predominantly …

Optogenetics at the presynapse

BR Rost, J Wietek, O Yizhar, D Schmitz - Nature neuroscience, 2022 - nature.com
Optogenetic actuators enable highly precise spatiotemporal interrogation of biological
processes at levels ranging from the subcellular to cells, circuits and behaving organisms …

Prefrontal–hippocampal interactions in episodic memory

H Eichenbaum - Nature Reviews Neuroscience, 2017 - nature.com
The roles of the hippocampus and prefrontal cortex (PFC) in memory processing—
individually or in concert—are a major topic of interest in memory research. These brain …

What, if anything, is rodent prefrontal cortex?

M Laubach, LM Amarante, K Swanson, SR White - eneuro, 2018 - eneuro.org
Prefrontal cortex (PFC) means different things to different people. In recent years, there has
been a major increase in publications on the PFC, especially using mice. However …

Integration of optogenetics with complementary methodologies in systems neuroscience

CK Kim, A Adhikari, K Deisseroth - Nature Reviews Neuroscience, 2017 - nature.com
Modern optogenetics can be tuned to evoke activity that corresponds to naturally occurring
local or global activity in timing, magnitude or individual-cell patterning. This outcome has …

The hippocampal sharp wave–ripple in memory retrieval for immediate use and consolidation

HR Joo, LM Frank - Nature Reviews Neuroscience, 2018 - nature.com
Various cognitive functions have long been known to require the hippocampus. Recently,
progress has been made in identifying the hippocampal neural activity patterns that …