As the home of cellular genetic information, the nucleus has a critical role in determining cell
fate and function in response to various signals and stimuli. In addition to biochemical …

Viewing metabolism through the lens of exercise biology has proven an accessible and
practical strategy to gain new insights into local and systemic metabolic regulation. Recent …

Although mutations leading to a compromised nuclear envelope cause diseases such as
muscular dystrophies or accelerated aging, the consequences of mechanically induced …

Arp2/3 complex is an actin filament nucleation and branching machinery conserved in all
eukaryotes from yeast to human. Arp2/3 complex branched networks generate pushing …

The ability of cells to respond to mechanical forces is critical for numerous biological
processes. Emerging evidence indicates that external mechanical forces trigger changes in …

Actin plays roles in many important cellular processes, including cell motility, organelle
movement, and cell signaling. The discovery of transmembrane actin-binding proteins at the …

Mutations in the LMNA gene, which encodes the nuclear envelope (NE) proteins lamins A/C,
cause Emery–Dreifuss muscular dystrophy, congenital muscular dystrophy and other …

Skeletal muscle cells possess a unique cellular architecture designed to fulfill their
contractile function. Muscle cells (also known as myofibers) result from the fusion of …

Topographical cues on cells can, through contact guidance, alter cellular plasticity and
accelerate the regeneration of cultured tissue. Here we show how changes in the nuclear …

Rationale: Mechanical forces are transduced to nuclear responses via the linkers of the
nucleoskeleton and cytoskeleton (LINC) complex, which couples the cytoskeleton to the …