Proximal tubule protein uptake is mediated by 2 receptors, megalin and cubilin. These
receptors rescue a variety of filtered ligands, including biomarkers, essential vitamins, and …

Membranous nephropathy (MN) is a glomerular disease that can occur at all ages. In adults,
it is the most frequent cause of nephrotic syndrome. In~ 80% of patients, there is no …

Enzyme replacement therapy (ERT) with recombinant α‐galactosidase A (r‐αGAL A) for the
treatment of Fabry disease has been available for over 15 years. Long‐term treatment may …

Mitochondrial dysfunction is considered as a key mediator in the pathogenesis of diabetic
nephropathy (DN). Therapeutic strategies targeting mitochondrial dysfunction hold …

Protein reabsorption is a predominant feature of the renal proximal tubule. Animal studies
show that the ability to rescue plasma proteins relies on the endocytic receptors megalin and …

Fabry disease (FD) is a lysosomal storage disorder (LSD) characterized by the deficiency of
α-galactosidase A (α-GalA) and the consequent accumulation of toxic metabolites such as …

The effect of early-onset enzyme replacement therapy on renal morphologic features in
Fabry disease is largely unknown. Here, we evaluated the effect of 5 years of treatment with …

Fabry disease (FD) is a lysosomal storage disorder caused by mutations of the GLA gene
that lead to a deficiency of the enzymatic activity of α-galactosidase A. Available therapies …

In adults, membranous nephropathy (MN) is a major cause of nephrotic syndrome. However,
the etiology of approximately 75% of MN cases is idiopathic. Secondary causes of MN are …

Fabry disease (FD) is an X-linked lysosomal storage disorder (LSD) caused by mutations of
the a-galactosidase A gene. The lysosomal enzyme a-galactosidase A (GLA) mediates the …