Chlorine is one of the most common atoms present in small-molecule drugs beyond carbon,
hydrogen, nitrogen, and oxygen. There are currently more than 250 FDA-approved chlorine …

The CB1 cannabinoid receptor is a G-protein coupled receptor highly expressed throughout
the central nervous system that is a promising target for the treatment of various disorders …

One of the key scientific aspects of small-molecule drug discovery and development is the
analysis of the relationship between its chemical structure and biological activity …

Cannabis is well established to impact affective states, emotion and perceptual processing,
primarily through its interactions with the endocannabinoid system. While cannabis use is …

It is hard to overestimate the influence of the endocannabinoid signaling (ECS) system on
central nervous system (CNS) function. In the 40 years since cannabinoids were found to …

Highlights•This review paper presents an overview of the recent findings on the allosteric
modulation of cannabinoid receptors.•Six categories of allosteric modulators have new …

Cannabis sativa contains more than 120 cannabinoids and 400 terpene compounds (ie,
phytomolecules) present in varying amounts. Cannabis is increasingly available for legal …

Orthosteric activation of CB1 is known to cause a plethora of adverse side effects in vivo.
Allosteric modulation is an exciting therapeutic approach and is hoped to offer improved …

Cannabis sativa is known for its therapeutic benefit in various diseases including pain relief
by targeting cannabinoid receptors. The primary component of cannabis, Δ9 …

Class AG protein‐coupled receptors (GPCRs) continue to garner interest for their essential
roles in cell signalling and their importance as drug targets. Although numerous drugs in the …