Vitamin K (VK), a fat-soluble vitamin, is well known as an anticoagulant in the clinic. It is
essential for the post-translational activation of VK-dependent proteins (VKDPs) because …

Objective Osteoarthritis (OA) is the most prevalent musculoskeletal disease affecting
articulating joint tissues, resulting in local and systemic changes that contribute to increased …

Despite the importance of vitamin K to maintaining normal growth, survival, and bone health
in fish, studies on the effect of different dietary levels of vitamin K on marine fish larvae are …

Objectives Erosive hand osteoarthritis (EHOA) is a severe subset of hand osteoarthritis (OA).
It is unclear if EHOA is genetically different from other forms of OA. Sequence variants at ten …

Osteoporosis (OP) is known as a silent disease in which the loss of bone mass and bone
density does not cause obvious symptoms, resulting in insufficient treatment and preventive …

Objectives: The pathophysiology of osteoarthritis is mainly unknown. Matrix Gla protein
(MGP) and Gla-rich protein (GRP) are both vitamin-K-dependent mineralization inhibitors. In …

Abstract Dysregulation of Wingless and Int‐1 (Wnt) signaling has been strongly associated
with development and progression of osteoarthritis (OA). Here, we set out to investigate the …

Objectives To study the mechanism by which the readthrough mutation in TNFRSF11B,
encoding osteoprotegerin (OPG) with additional 19 amino acids at its C-terminus (OPG-XL) …

Objective Due to the complexity and heterogeneity of osteoarthritis (OA) pathophysiology,
studying the interaction between intrinsic molecular changes in chondrocytes after hyper …

An imbalance of human mesenchymal stem cells (MSCs) adipogenic and osteogenic
differentiation plays an important role in the pathogenesis of osteoporosis. Our previous …