Inflammation is intimately related to the pathogenesis of numerous acute and chronic
diseases like cardiovascular disease, inflammatory bowel disease, rheumatoid arthritis, and …

Macrophage is the key innate immune effector in first-line defense against the pathogens,
and can be polarized into different phenotypes to regulate a variety of immunological …

Abstract Background Glucocorticoids (GCs) show powerful treatment effect on rheumatoid
arthritis (RA). However, the clinical application is limited by their nonspecific distribution after …

The transcription factor NF-kB plays a pivotal role in the pathogenesis of rheumatoid arthritis.
Here we attempt to slow arthritis progression by co-delivering the glucocorticoid …

Polymer nanomedicines (macromolecular therapeutics, polymer-drug conjugates, drug-free
macromolecular therapeutics) are a group of biologically active compounds that are …

Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease characterized by
synovial inflammation, cartilage damage and bone erosion. In the progression of RA, the …

The discovery of X-rays app. 120 years ago changed dramatically the diagnostic
capabilities. Since then, there have been many advances in medicine, which have had more …

While glucocorticoids have been used for over 50 years to treat rheumatoid and
osteoarthritis pain, the prescription of glucocorticoids remains controversial because of …

Rheumatoid arthritis (RA) is a severe systemic inflammatory disease. It is often associated
with serious cartilage destruction and massive inflammatory infiltration, which might …

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease, which is characterized
by synovial inflammation and autoimmunity. The main cause of the disease is the imbalance …