The multifaceted role of glutathione S-transferases in cancer

A Chatterjee, S Gupta - Cancer letters, 2018 - Elsevier
Glutathione S-transferases (GSTs) are phase II detoxifying enzymes involved in the
maintenance of cell integrity, oxidative stress and protection against DNA damage by …

Glutathione transferases: potential targets to overcome chemoresistance in solid tumors

M Pljesa-Ercegovac, A Savic-Radojevic… - International journal of …, 2018 - mdpi.com
Multifunctional enzymes glutathione transferases (GSTs) are involved in the development of
chemoresistance, thus representing a promising target for a novel approach in cancer …

Cytoprotective and regulatory functions of glutathione S-transferases in cancer cell proliferation and cell death

S Singh - Cancer chemotherapy and pharmacology, 2015 - Springer
Abstract Purpose Glutathione S-transferases (GSTs) family of enzymes is best known for
their cytoprotective role and their involvement in the development of anticancer drug …

[HTML][HTML] Molecular evaluation of glutathione S transferase family genes in patients with sporadic colorectal cancer

GH Rodrigues-Fleming… - World journal of …, 2018 - ncbi.nlm.nih.gov
AIM To evaluate the association between polymorphisms in glutathione S transferases
(GSTs) and the risk of sporadic colorectal cancer (SCRC), tumor progression and the …

The Upregulation of GSTO2 is Associated with Colon Cancer Progression and a Poor Prognosis

X Peng, J Zhu, S Liu, Z Liu, C Luo, X Wu… - Journal of …, 2023 - Wiley Online Library
Colorectal cancer is the second‐leading cause of cancer‐related mortality in the United
States. Glutathione S‐transferase can affect the development of cancer. Glutathione S …

Glutathione S-transferase enzyme activity and protein expression in patients with recurrent tonsillitis and idiopathic tonsillar hypertrophy

S Aydin, M Demir, S OĞUZTÜZÜN… - BIOMEDICAL …, 2019 - avesis.ankara.edu.tr
Objectives. The palatine tonsil is a significant part of the secondary immune system.
Tonsillitis and idiopathic tonsillar hypertrophy (ITH) are the most common pathologies of this …

[PDF][PDF] Enzyme induction and cytotoxicity of phenethyl isothiocyanate and its glutathione conjugate towards breast cancer cells

YS Lam, R Owusu-Apenten - Pure and Applied Chemical Sciences, 2013 - Citeseer
Chemoprevention using isothiocyanates is partly the result of the induction of phase II
enzymes for carcinogen detoxification from healthy cells. However, phase II enzyme activity …

[PDF][PDF] The Upregulation of GSTO2 is Associated with Colon Cancer Progression and a Poor Prognosis

X Wu, Z Yu, Z Zhu - 2023 - scienceopen.com
Ten, we used Perl to process mRNA data and get 473 colon cancer samples and 41 normal
tissue samples. In the same way, 453 colon cancer patients' clinical data were downloaded …

INVESTIGATION OF GST AND DRUG RESISTANCE PROTEIN EXPRESSIONS IN RELATION TO CHEMOTHERAPY IN BREAST CANCER

AK Kocdogan, M Kilic, S Oguztuzun, E Benzer… - Health Problems of … - termedia.pl
Background During cancer therapy, resistance to chemotherapeutic agents is common and
often linked to multidrug resistance mechanisms. Glutathione S-transferases (GSTs) and …

[PDF][PDF] Synergy between thiazolides and glutathione-S-transferases in cell death induction in colorectal tumor cells

P Ripani - 2019 - kops.uni-konstanz.de
Colorectal cancer (CRC) is the third leading cause of cancer-related deaths worldwide.
Chemotherapy remains the first line treatment for advanced and metastatic CRC stages …