CD 4+ T‐helper cells regulate immunity and inflammation through the acquisition of
potential to secrete specific cytokines. The acquisition of cytokine‐secreting potential, in a …

Asthma is a complex disease with a diverse genetic and environmental component. 1
Asthma shows a high level of phenotypic heterogeneity characterised by obstruction of the …

Background Gene-environment interaction studies using genome-wide association study
data are often underpowered after adjustment for multiple comparisons. Differential gene …

Background IL-9 and its receptor play important roles in the pathogenesis of asthma. Its role
in atopic dermatitis (AD) was examined in just a few studies, including nucleotide …

Sex differences in asthma-associated phenotypes are well known but the genetic factors that
may account for these differences have received little attention. This study aimed to …

The mechanism underlying late-phase allergic reactions (LPR) remains incompletely
understood. This study aimed to investigate the role of a newly described subset of T cells …

Background: Asthma is a chronic inflammatory disease of airways which accounts for a huge
economic, morbidity, and mortality burden. There are different cytokines that contribute to …

Genetic studies have shown linkages for asthma to the chromosomal region 5q31–q33 in
humans that includes the IL-9 gene. An A-to-G base substitution has been identified at bp …

Studies have shown linkage between microsatellite markers from the chromosome 5q31‐
q33 region with asthma, atopy and total IgE levels in the Singapore Chinese population …

Purpose: We aim to discuss the current status of knowledge on the role of recently identified
cytokines in airway hyper responsiveness as well as the genetic predisposition conferred by …