Targeting transcription factors in cancer—from undruggable to reality
JH Bushweller - Nature Reviews Cancer, 2019 - nature.com
Mutated or dysregulated transcription factors represent a unique class of drug targets that
mediate aberrant gene expression, including blockade of differentiation and cell death gene …
mediate aberrant gene expression, including blockade of differentiation and cell death gene …
Lineage-specific and single-cell chromatin accessibility charts human hematopoiesis and leukemia evolution
We define the chromatin accessibility and transcriptional landscapes in 13 human primary
blood cell types that span the hematopoietic hierarchy. Exploiting the finding that the …
blood cell types that span the hematopoietic hierarchy. Exploiting the finding that the …
Subtype-specific regulatory network rewiring in acute myeloid leukemia
SA Assi, MR Imperato, DJL Coleman, A Pickin… - Nature …, 2019 - nature.com
Acute myeloid leukemia (AML) is a heterogeneous disease caused by a variety of
alterations in transcription factors, epigenetic regulators and signaling molecules. To …
alterations in transcription factors, epigenetic regulators and signaling molecules. To …
[HTML][HTML] Molecular basis of hematological disease caused by inherited or acquired RUNX1 mutations
Highlights•Germline and acquired RUNX1 mutations are associated with FPD and
MDS/AML.•Large deletions and nonsense mutations are more common in germline FPD …
MDS/AML.•Large deletions and nonsense mutations are more common in germline FPD …
RIPK3 restricts myeloid leukemogenesis by promoting cell death and differentiation of leukemia initiating cells
Since acute myeloid leukemia (AML) is characterized by the blockade of hematopoietic
differentiation and cell death, we interrogated RIPK3 signaling in AML development. Genetic …
differentiation and cell death, we interrogated RIPK3 signaling in AML development. Genetic …
Inhibition of the succinyl dehydrogenase complex in acute myeloid leukemia leads to a lactate-fuelled respiratory metabolic vulnerability
Metabolic programs can differ substantially across genetically distinct subtypes of acute
myeloid leukemia (AML). These programs are not static entities but can change swiftly as a …
myeloid leukemia (AML). These programs are not static entities but can change swiftly as a …
Prospective isolation and characterization of genetically and functionally distinct AML subclones
Intra-tumor heterogeneity caused by clonal evolution is a major problem in cancer treatment.
To address this problem, we performed label-free quantitative proteomics on primary acute …
To address this problem, we performed label-free quantitative proteomics on primary acute …
Transcriptional reprogramming by mutated IRF4 in lymphoma
Disease-causing mutations in genes encoding transcription factors (TFs) can affect TF
interactions with their cognate DNA-binding motifs. Whether and how TF mutations impact …
interactions with their cognate DNA-binding motifs. Whether and how TF mutations impact …
[HTML][HTML] Gene regulatory network analysis predicts cooperating transcription factor regulons required for FLT3-ITD+ AML growth
Acute myeloid leukemia (AML) is a heterogeneous disease caused by different mutations.
Previously, we showed that each mutational subtype develops its specific gene regulatory …
Previously, we showed that each mutational subtype develops its specific gene regulatory …
Mutational synergy during leukemia induction remodels chromatin accessibility, histone modifications and three-dimensional DNA topology to alter gene expression
Altered transcription is a cardinal feature of acute myeloid leukemia (AML); however, exactly
how mutations synergize to remodel the epigenetic landscape and rewire three-dimensional …
how mutations synergize to remodel the epigenetic landscape and rewire three-dimensional …