This review is focused on purinergic neurotransmission, ie, ATP released from nerves as a
transmitter or cotransmitter to act as an extracellular signaling molecule on both pre-and …

There have been many advances in our knowledge about different aspects of P2Y receptor
signaling since the last review published by our International Union of Pharmacology …

Purines have key roles in neurotransmission and neuromodulation, with their effects being
mediated by the purine and pyrimidine receptor subfamilies, P1, P2X and P2Y. Recently …

The concept of a purinergic signaling system, using purine nucleotides and nucleosides as
extracellular messengers, was first proposed over 30 years ago. After a brief introduction …

Purinergic signalling appears to play important roles in neurodegeneration, neuroprotection
and neuroregeneration. Initially there is a brief summary of the background of purinergic …

Astrocytes are fundamental for central nervous system (CNS) physiology and are the fulcrum
of neurological diseases. Astroglial cells control development of the nervous system …

P2 receptors for extracellular nucleotides are divided into two categories: the ion channel
receptors (P2X) and the G-protein-coupled receptors (P2Y). For the P2X receptors, signal …

Purinergic transmission is one of the most ancient and widespread extracellular signalling
systems. In the brain, purinergic signalling plays a unique role in integrating neuronal and …

There is a widespread presence of both adenosine (P1) and P2 nucleotide receptors in the
brain on both neurones and glial cells. Adenosine receptors play a major role in presynaptic …

The development of the nervous system requires complex series of cellular programming
and intercellular communication events that lead from the early neural induction to the …