Development of prefrontal cortex
During evolution, the cerebral cortex advances by increasing in surface and the introduction
of new cytoarchitectonic areas among which the prefrontal cortex (PFC) is considered to be …
of new cytoarchitectonic areas among which the prefrontal cortex (PFC) is considered to be …
Neuroplasticity in cognitive and psychological mechanisms of depression: an integrative model
Chronic stress and depressive-like behaviors in basic neuroscience research have been
associated with impairments of neuroplasticity, such as neuronal atrophy and synaptic loss …
associated with impairments of neuroplasticity, such as neuronal atrophy and synaptic loss …
Harnessing psilocybin: antidepressant-like behavioral and synaptic actions of psilocybin are independent of 5-HT2R activation in mice
N Hesselgrave, TA Troppoli, AB Wulff… - Proceedings of the …, 2021 - National Acad Sciences
Depression is a widespread and devastating mental illness and the search for rapid-acting
antidepressants remains critical. There is now exciting evidence that the psychedelic …
antidepressants remains critical. There is now exciting evidence that the psychedelic …
Mechanisms of ketamine action as an antidepressant
Clinical studies have demonstrated that a single sub-anesthetic dose of the dissociative
anesthetic ketamine induces rapid and sustained antidepressant actions. Although this …
anesthetic ketamine induces rapid and sustained antidepressant actions. Although this …
Prefrontal cortex circuits in depression and anxiety: contribution of discrete neuronal populations and target regions
Our understanding of depression and its treatment has advanced with the advent of
ketamine as a rapid-acting antidepressant and the development and refinement of tools …
ketamine as a rapid-acting antidepressant and the development and refinement of tools …
Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways
Depression is a polygenic trait that causes extensive periods of disability. Previous genetic
studies have identified common risk variants which have progressively increased in number …
studies have identified common risk variants which have progressively increased in number …
The inositol trisphosphate/calcium signaling pathway in health and disease
MJ Berridge - Physiological reviews, 2016 - journals.physiology.org
Many cellular functions are regulated by calcium (Ca2+) signals that are generated by
different signaling pathways. One of these is the inositol 1, 4, 5-trisphosphate/calcium …
different signaling pathways. One of these is the inositol 1, 4, 5-trisphosphate/calcium …
Mechanisms of ketamine and its metabolites as antidepressants
EM Hess, LM Riggs, M Michaelides… - Biochemical pharmacology, 2022 - Elsevier
Treating major depression is a medical need that remains unmet by monoaminergic
therapeutic strategies that commonly fail to achieve symptom remission. A breakthrough in …
therapeutic strategies that commonly fail to achieve symptom remission. A breakthrough in …
Reward behaviour is regulated by the strength of hippocampus–nucleus accumbens synapses
Reward drives motivated behaviours and is essential for survival, and therefore there is
strong evolutionary pressure to retain contextual information about rewarding stimuli. This …
strong evolutionary pressure to retain contextual information about rewarding stimuli. This …
Dendritic spines: Revisiting the physiological role
SB Chidambaram, AG Rathipriya, SR Bolla… - Progress in Neuro …, 2019 - Elsevier
Dendritic spines are small, thin, specialized protrusions from neuronal dendrites, primarily
localized in the excitatory synapses. Sophisticated imaging techniques revealed that …
localized in the excitatory synapses. Sophisticated imaging techniques revealed that …