Human cancers share properties referred to as hallmarks, among which sustained
proliferation, escape from apoptosis, and genomic instability are the most pervasive. The …

Deletions and duplications of chromosomal segments (copy number variants, CNVs) are a
major source of variation between individual humans and are an underlying factor in human …

The CRISPR-Cas9 system has revolutionized our ability to precisely modify the genome and
has led to gene editing in clinical applications. Comprehensive analysis of gene editing …

The mechanisms underlying the low efficiency of reprogramming somatic cells into induced
pluripotent stem (iPS) cells are poorly understood. There is a clear need to study whether …

Ever since initial suggestions that instability at common fragile sites (CFSs) could be
responsible for chromosome rearrangements in cancers, CFSs and associated genes have …

Telomeres protect chromosome ends through the interaction of telomeric repeats with
shelterin, a protein complex that represses DNA damage signaling and DNA repair …

The cancer genome is moulded by the dual processes of somatic mutation and selection.
Homozygous deletions in cancer genomes occur over recessive cancer genes, where they …

Advanced paternal age has been associated with an increased risk for spontaneous
congenital disorders and common complex diseases (such as some cancers, schizophrenia …

Like their nuclear counterpart, the plastid and mitochondrial genomes of plants have to be
faithfully replicated and repaired to ensure the normal functioning of the plant. Inability to …

During the last two decades, the importance of human genome copy number variation
(CNV) in disease has become widely recognized. However, much is not understood about …