mTORC2–NDRG1–CDC42 axis couples fasting to mitochondrial fission

N Martinez-Lopez, P Mattar, M Toledo, H Bains… - Nature Cell …, 2023 - nature.com
Fasting triggers diverse physiological adaptations including increases in circulating fatty
acids and mitochondrial respiration to facilitate organismal survival. The mechanisms driving …

Mitochondrial networks through the lens of mathematics

GR Lewis, WF Marshall - Physical biology, 2023 - iopscience.iop.org
Mitochondria serve a wide range of functions within cells, most notably via their production
of ATP. Although their morphology is commonly described as bean-like, mitochondria often …

[HTML][HTML] E4 ubiquitin ligase promotes mitofusin turnover and mitochondrial stress response

V Anton, I Buntenbroich, T Simões, M Joaquim… - Molecular Cell, 2023 - cell.com
Ubiquitin-dependent control of mitochondrial dynamics is important for protein quality and
neuronal integrity. Mitofusins, mitochondrial fusion factors, can integrate cellular stress …

Docking and stability defects in mitofusin highlight the proteasome as a potential therapeutic target

I Buntenbroich, V Anton, D Perez-Hernandez, T Simões… - Iscience, 2023 - cell.com
Defects in mitochondrial fusion are at the base of many diseases. Mitofusins power
membrane-remodeling events via self-interaction and GTP hydrolysis. However, how exactly …

Coupling of mitochondrial population evolution to microtubule dynamics in fission yeast cells: a kinetic Monte Carlo study

S Choudhury, V Ananthanarayanan, KG Ayappa - Soft Matter, 2022 - pubs.rsc.org
Mitochondrial populations in cells are maintained by cycles of fission and fusion events.
Perturbation of this balance has been observed in several diseases such as cancer and …

mTORC2 couples fasting to mitochondrial fission

N Martinez-Lopez, P Mattar, M Toledo, H Bains… - bioRxiv, 2022 - biorxiv.org
Fasting triggers diverse cellular and metabolic adaptations to facilitate organismal survival,.
During nutrient deprivation, increases in circulating fatty acids support mitochondrial …

Microtubule dynamics and the evolution of mitochondrial populations in fission yeast cells: A kinetic Monte Carlo study

S Choudhury, V Ananthanarayanan, KG Ayappa - bioRxiv, 2021 - biorxiv.org
Mitochondrial populations in cells are maintained by cycles of fission and fusion events.
Perturbation of this balance has been observed in several diseases such as cancer and …

[PDF][PDF] Investigating fungal cellular processes involved in early colonisation of wheat by Zymoseptoria tritici

H Child - 2021 - ore.exeter.ac.uk
The fungal pathogen Zymoseptoria tritici causes the most economically important disease of
wheat in Europe. Despite recent advances in our understanding of its molecular host …