The expanding universe of PARP1-mediated molecular and therapeutic mechanisms
D Huang, WL Kraus - Molecular cell, 2022 - cell.com
ADP-ribosylation (ADPRylation) is a post-translational modification of proteins catalyzed by
ADP-ribosyl transferase (ART) enzymes, including nuclear PARPs (eg, PARP1 and PARP2) …
ADP-ribosyl transferase (ART) enzymes, including nuclear PARPs (eg, PARP1 and PARP2) …
ADP-ribosylation from molecular mechanisms to therapeutic implications
ADP-ribosylation is a ubiquitous modification of biomolecules, including proteins and
nucleic acids, that regulates various cellular functions in all kingdoms of life. The recent …
nucleic acids, that regulates various cellular functions in all kingdoms of life. The recent …
PARP14 is a PARP with both ADP-ribosyl transferase and hydrolase activities
N Đukić, Ø Strømland, JD Elsborg, D Munnur, K Zhu… - Science …, 2023 - science.org
PARP14 is a mono–ADP-ribosyl transferase involved in the control of immunity,
transcription, and DNA replication stress management. However, little is known about the …
transcription, and DNA replication stress management. However, little is known about the …
The multifaceted roles of PARP1 in DNA repair and chromatin remodelling
A Ray Chaudhuri, A Nussenzweig - Nature reviews Molecular cell …, 2017 - nature.com
Cells are exposed to various endogenous and exogenous insults that induce DNA damage,
which, if unrepaired, impairs genome integrity and leads to the development of various …
which, if unrepaired, impairs genome integrity and leads to the development of various …
PARPs and ADP-ribosylation: recent advances linking molecular functions to biological outcomes
The discovery of poly (ADP-ribose)> 50 years ago opened a new field, leading the way for
the discovery of the poly (ADP-ribose) polymerase (PARP) family of enzymes and the ADP …
the discovery of the poly (ADP-ribose) polymerase (PARP) family of enzymes and the ADP …
Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2
S Gahbauer, GJ Correy, M Schuller… - Proceedings of the …, 2023 - National Acad Sciences
The nonstructural protein 3 (NSP3) of the severe acute respiratory syndrome-coronavirus-2
(SARS-CoV-2) contains a conserved macrodomain enzyme (Mac1) that is critical for …
(SARS-CoV-2) contains a conserved macrodomain enzyme (Mac1) that is critical for …
Insights into the biogenesis, function, and regulation of ADP-ribosylation
MS Cohen, P Chang - Nature chemical biology, 2018 - nature.com
ADP-ribosylation—the transfer of ADP-ribose (ADPr) from NAD+ onto target molecules—is
catalyzed by members of the ADP-ribosyltransferase (ART) superfamily of proteins, found in …
catalyzed by members of the ADP-ribosyltransferase (ART) superfamily of proteins, found in …
Family-wide analysis of poly (ADP-ribose) polymerase activity
S Vyas, I Matic, L Uchima, J Rood, R Zaja… - Nature …, 2014 - nature.com
The poly (adenosine diphosphate (ADP)-ribose) polymerase (PARP) protein family
generates ADP-ribose (ADPr) modifications onto target proteins using NAD+ as substrate …
generates ADP-ribose (ADPr) modifications onto target proteins using NAD+ as substrate …
Serine ADP-ribosylation depends on HPF1
JJ Bonfiglio, P Fontana, Q Zhang, T Colby… - Molecular cell, 2017 - cell.com
ADP-ribosylation (ADPr) regulates important patho-physiological processes through its
attachment to different amino acids in proteins. Recently, by precision mapping on all …
attachment to different amino acids in proteins. Recently, by precision mapping on all …
ADP-ribosylation, a multifaceted posttranslational modification involved in the control of cell physiology in health and disease
B Lüscher, M Bütepage, L Eckei, S Krieg… - Chemical …, 2018 - ACS Publications
Posttranslational modifications (PTMs) regulate protein functions and interactions. ADP-
ribosylation is a PTM, in which ADP-ribosyltransferases use nicotinamide adenine …
ribosylation is a PTM, in which ADP-ribosyltransferases use nicotinamide adenine …