[HTML][HTML] Genetics of male infertility: from research to clinic

C Krausz, AR Escamilla, C Chianese - Reproduction, 2015 - rep.bioscientifica.com
Male infertility is a multifactorial complex disease with highly heterogeneous phenotypic
representation and in at least 15% of cases, this condition is related to known genetic …

Genetic variations as molecular diagnostic factors for idiopathic male infertility: current knowledge and future perspectives

M Karimian, L Parvaresh, M Behjati - Expert Review of Molecular …, 2021 - Taylor & Francis
Introduction Infertility is a major health problem, worldwide, which affects 10–15% of
couples. About half a percent of infertility cases are related to male-related factors. Male …

[HTML][HTML] Nitric oxide, 8-hydroxydeoxyguanosine, and total antioxidant capacity in human seminal plasma of infertile men and their relationship with sperm parameters

M Gholinezhad, A Aliarab… - Clinical and …, 2020 - ncbi.nlm.nih.gov
Objective Oxidative stress plays a key role in the pathogenesis of male infertility. But, the
adverse effects of oxidative biomarkers on sperm quality remain unclear. This study aimed to …

[HTML][HTML] Genetic variants in nitric oxide synthase genes and the risk of male infertility in a Chinese population: A case-control study

L Yan, W Guo, S Wu, J Liu, S Zhang, L Shi, G Ji, A Gu - PloS one, 2014 - journals.plos.org
Background In recent years, oxidative stress has been studied extensively as a main
contributing factor to male infertility. Nitric Oxide, a highly reactive free radical gas, is …

Endothelial nitric oxide synthase (eNOS) T-786C, 4a4b, and G894T polymorphisms and male infertility: study for idiopathic asthenozoospermia and meta-analysis

P Song, S Zou, T Chen, J Chen, Y Wang… - Biology of …, 2015 - academic.oup.com
Recent studies on the eNOS gene and male infertility show that expression of eNOS
regulates normal spermatogenesis in the testis, and the eNOS gene variants (T-786C, 4a4b …

Genome‐Wide Association Study for Sperm Concentration in Holstein‐Friesian Bulls

DM Hering, K Olenski… - Reproduction in domestic …, 2014 - Wiley Online Library
Contents The aim of the study was to screen the entire bull genome to identify markers and
candidate genes underlying sperm concentration. The analysed data set originates from a …

NOS3 gene variants and male infertility: Association of 4a/4b with oligoasthenozoospermia

NLJ Vučić, ZZ Nikolić, VD Vukotić, SM Tomović… - Andrologia, 2018 - Wiley Online Library
Results of recent studies confirmed that oxidative stress negatively affects sperm motility and
causes sperm DNA damage. Produced by nitric oxide synthase 3 (NOS 3), nitric oxide is …

Endothelial nitric oxide synthase gene polymorphism relationship with semen parameters and oxidative stress in infertile oligoasthenoteratozoospermic men

T Mostafa, LA Rashed, N Nabil, H Fouad, D Sabry… - Urology, 2015 - Elsevier
Objective To assess endothelial nitric oxide synthase (eNOS) gene polymorphism
relationship with semen parameters and oxidative stress in infertile …

Genetic variants of eNOS gene may modify the susceptibility to idiopathic male infertility

HQ Ying, XY Pu, SR Liu - Biomarkers, 2013 - Taylor & Francis
In testis, eNOS is responsible for synthesis of nitric oxide (NO) which is an essential gas
message regulator in spermatogenesis, suggesting that eNOS gene plays a role in normal …

The Relationship Between Endothelial Nitric Oxide Synthase Gene (NOS3) Polymorphisms, NOS3 Expression, and Varicocele

CY Kahraman, S Tasdemir, I Sahin… - Genetic testing and …, 2016 - liebertpub.com
Background: Varicocele is an abnormal enlargement of the pampiniform venous plexus in
the scrotum. Varicocele is the most common cause of secondary male infertility. Nitric oxide …