Autophagy is an evolutionarily conserved multistep degradation mechanism in eukaryotes,
that maintains cellular homoeostasis by replenishing cells with nutrients through catabolic …

Autophagosome formation requires sequential translocation of autophagy-specific proteins
to membranes enriched in PI3P and connected to the ER. Preceding this, the earliest …

Autophagy is a catabolic pathway required for the recycling of cytoplasmic materials. To
define the mechanisms underlying autophagy it is critical to quantitatively characterize the …

Autophagy is a degradation process in eukaryotic cells that recycles cellular components for
nutrition supply under environmental stress and plays a double-edged role in development …

Hepatitis C virus (HCV) induces autophagy to promote its replication, including its RNA
replication, which can take place on double-membrane vesicles known as …

Background Mechanical loading has been widely considered to be essential for growth
plate to maintain metabolism and development. Cyclic mechanical strain has been …

Autophagy is a specialized catabolic process that selectively degrades cytoplasmic
components, including proteins and damaged organelles. Autophagy allows cells to …

Autophagosomes form in eukaryotic cells in response to starvation or to other stress
conditions brought about by the unwanted presence in the cytosol of pathogens, damaged …

Autophagy is a catabolic pathway required for the clearance and recycling of cytoplasmic
materials. Upregulation and dysfunction of autophagy contributes to the pathology of cancer …

Autophagy is a highly dynamic intracellular process involving interactions between protein
complexes and membranes. Direct observation of these components in living cells provides …