Benzyloxy anilide derivatives useful as potassium channel modulators

JZ Wu, JM Vernier, H Chen, J Song - US Patent 8,188,314, 2012 - Google Patents
Epilepsy is a well-known neurological disease, found in about 3% of the population.
Approximately 30% of patients with epilepsy do not respond to currently available therapies …

Naphthyridine derivatives as potassium channel modulators

JM Vernier, M de la Rosa - US Patent 8,563,566, 2013 - Google Patents
4,181,803 A 1, 1980 Morita et al. 4,554.281 A 11/1985 vonBebenburg et al. 4,668,684 A 5,
1987 Tibes et al. 4,778,799 A 10, 1988 Tibes et al. 4,923,858 A 5/1990 Engel et al …

ATGListatin and pharmaceutical composition comprising the same

M Schweiger, M Romauch, R Zimmermann… - US Patent …, 2015 - Google Patents
(R) is useful in the treatment and prevention of a disorder Such as cachexia, stroke,
atherosclerosis, coronary artery disease, and diabetes and pharmaceutical compositions of …

Methods for diagnosing bone or cardiovascular disorders

J Grillari, E Schraml, K Fortschegger… - US Patent 9,150,855, 2015 - Google Patents
The invention relates to methods for diagnosing bone disorders and/or cardiovascular
disorders in a subject, by contacting a biological sample from the subject with (a) a nucleic …

Modulation of KCNQ potassium channel activity for treatment of psychiatric disorders and the symptoms thereof

MB Ghasemzadeh - US Patent 9,017,735, 2015 - Google Patents
Disclosed herein are compositions and methods for treating a psychiatric disorder or
symptoms thereof in a patient. The compositions comprise a compound that modulates …

N-[2-amino-4-(phenylmethoxy) phenyl] amides and related compounds as potassium channel modulators

JM Vernier, J Song, H Chen, Z Hong - US Patent 8,722,929, 2014 - Google Patents
4,181,803 A 1, 1980 Morita et al. 4,554.281 A 11/1985 vonBebenburg et al. 4,668,684 A 5,
1987 Tibes et al. 4,778,799 A 10, 1988 Tibes et al. 4,923,858 A 5/1990 Engel et al …

Open Access to the KCNQ Channel: Retigabine and Second Generation M-current Openers

J Krupp, AM Rush, BM Swahn, M Main - 2014 - books.rsc.org
Potassium channels form the largest group of ion channels in the human genome, with
approximately 78 pore-forming 'alpha'subunits and 13 auxiliary 'beta'subunits identified to …

Benzyloxy anilide derivatives useful as potassium channel modulators

JZ Wu, JM Vernier, H Chen, J Song - US Patent 8,492,588, 2013 - Google Patents
This application is a divisional application of Ser. No. 12/491,055, filed on Jun. 24, 2009,
now US Pat. No. 8,188, 314, which claims the benefit of priority of US provisional application …

Combinations of retigabine and sodium channel inhibitors or sodium channel-influencing active compounds for treating pains

I Szelenyi, K Brune, R Hermann… - US Patent App. 12 …, 2010 - Google Patents
US20100323987A1 - Combinations of retigabine and sodium channel inhibitors or sodium
channel-influencing active compounds for treating pains - Google Patents …

Substituted aniline derivatives

CW Tornoe, M Rottlãnder, DR Greve… - US Patent App. 12 …, 2010 - Google Patents
A6II 3/167(2006.01) CD7C 23.3/0(2006.01) C07C 27I/28(2006.01) CD7C 33.3/08(2006.01)
C07D 239/02(2006.01) C07D 213/63(2006.01) C07D 33.3/02(2006.01) C07D …