Astrocyte dysfunction in Alzheimer disease

C Acosta, HD Anderson… - Journal of neuroscience …, 2017 - Wiley Online Library
Astrocytes are glial cells that are distributed throughout the central nervous system in an
arrangement optimal for chemical and physical interaction with neuronal synapses and …

[HTML][HTML] Reactive astrocytes: The nexus of pathological and clinical hallmarks of Alzheimer's disease

BR Price, LA Johnson, CM Norris - Ageing research reviews, 2021 - Elsevier
Astrocyte reactivity is a hallmark of neuroinflammation that arises with Alzheimer's disease
(AD) and nearly every other neurodegenerative condition. While astrocytes certainly …

Attention and executive deficits in Alzheimer's disease: A critical review

RJ Perry, JR Hodges - Brain, 1999 - academic.oup.com
In this review we summarize the progress that has been made in the research on attentional
and executive deficits in Alzheimer's disease. Like memory, attention is now recognized as …

Structural insights into aberrant topological patterns of large-scale cortical networks in Alzheimer's disease

Y He, Z Chen, A Evans - Journal of Neuroscience, 2008 - Soc Neuroscience
Recent research on Alzheimer's disease (AD) has shown that cognitive and memory decline
in this disease is accompanied by disrupted changes in the coordination of large-scale brain …

CLOX: an executive clock drawing task

DR Royall, JA Cordes, M Polk - Journal of Neurology, Neurosurgery …, 1998 - jnnp.bmj.com
OBJECTIVE To describe a clock drawing task (CLOX) designed to elicit executive
impairment and discriminate it from non-executive constructional failure. SUBJECTS 90 …

Individual differences in rates of change in cognitive abilities of older persons.

RS Wilson, LA Beckett, LL Barnes… - Psychology and …, 2002 - psycnet.apa.org
The authors examined change in cognitive abilities in older Catholic clergy members. For up
to 6 years, participants underwent annual clinical evaluations, which included a battery of …

Need-driven dementia-compromised behavior: An alternative view of disruptive behavior

DL Algase, C Beck, A Kolanowski… - American Journal of …, 1996 - journals.sagepub.com
The disruptive behavior of persons with dementia is a problem of considerable clinical
interest and growing scientific concern. This paper offers a view of these behaviors as …

Brain glucose hypometabolism and oxidative stress in preclinical Alzheimer's disease

L Mosconi, A Pupi, MJ De Leon - … of the New York Academy of …, 2008 - Wiley Online Library
One of the main features of Alzheimer's disease (AD) is the severe reduction of the cerebral
metabolic rate for glucose (CMRglc). In vivo imaging using positron emission tomography …

[HTML][HTML] Glucose metabolism in normal aging and Alzheimer's disease: methodological and physiological considerations for PET studies

L Mosconi - Clinical and translational imaging, 2013 - Springer
Alzheimer's disease (AD) is an age-dependent neurodegenerative disorder associated with
progressive loss of cognitive function. 2-[18 F] fluoro-2-deoxy-d-glucose (FDG) positron …

Discrimination between Alzheimer dementia and controls by automated analysis of multicenter FDG PET

K Herholz, E Salmon, D Perani, JC Baron, V Holthoff… - Neuroimage, 2002 - Elsevier
A new diagnostic indicator of FDG PET scan abnormality, based on age-adjusted t statistics
and an automated voxel-based procedure, is presented and validated in a large data set …