In 2020, fentanyl and its analogs contributed to~ 65% of drug-attributed fatalities in the USA,
with a threatening increasing trend during the last ten years. These synthetic opioids used …

Drug-related fatal overdoses have significantly increased in the past decade due to the
widespread availability of illicit fentanyl and other potent synthetic opioids such as …

Background A significant number of deaths caused by opioids involve fentanyl and/or one of
its very potent analogs (eg, carfentanil). Some clinical reports suggest larger doses of opioid …

The purpose of the analysis was to evaluate if 10 mg naloxone, administered
intramuscularly, could reverse or prevent opioid‐induced respiratory depression (OIRD) …

Drug overdose deaths involving synthetic opioids, primarily fentanyl, have risen dramatically
over the past decade and are currently the driving force of the opioid epidemic in the United …

Rationale Carfentanil, an opioid 10K times more potent than morphine, has no licit clinical
use. A powerful CNS depressant, it has been identified increasingly as the cause of …

Carfentanil is a synthetic opioid restricted to veterinary use due to its potency. Public health
concerns have been raised as to the potential of carfentanil to exhibit toxicity after absorption …

Opioid use disorders (OUD) and overdose are public health crises that are worsening
despite the availability of approved pharmacotherapies. Active immunization with anti-opioid …