Trehalose is a nonreducing disaccharide composed of two glucose molecules linked by α, α‐
1, 1‐glycosidic bond. It is present in a wide variety of organisms, including bacteria, fungi …

Trehalose is a naturally occurring, non-reducing disaccharide comprising two covalently-
linked glucose molecules. It possesses unique physiochemical properties, which account for …

Autophagy is a catabolic process that degrades cytoplasmic constituents and organelles in
the lysosome, thus serving an important role in cellular homeostasis and protection against …

Traumatic brain injury is one of the leading causes of mortality and morbidity in the world
with no current pharmacological treatment. The role of BDNF in neural repair and …

Induction of autophagy is a prospective approach to the treatment of neurodegeneration. In
the recent decade, trehalose attracted special attention. It is an autophagy inducer with …

The neuroprotective effect of autophagy activation by rapamycin and trehalose was studied
in a mouse model of Parkinson's disease (PD) induced by neurotoxin 1-methyl-4-phenyl-1 …

As Western diets continue to include an ever-increasing amount of sugar, there has been a
rise in obesity and type 2 diabetes. To avoid metabolic diseases, the body must maintain …

Neurotrophins are a collection of structurally and functionally related proteins. They play
important roles in many aspects of neural development, survival, and plasticity. Traumatic …

Elderly patients with traumatic brain injury (TBI) have greater mortality and poorer outcomes
than younger individuals. The extent to which old age alters long-term recovery and chronic …

Traumatic brain injury (TBI) is one of the most devastating forms of brain injury. Many
pathological mechanisms such as oxidative stress, apoptosis and inflammation all contribute …