[HTML][HTML] Therapeutic glycoprotein production in mammalian cells
ME Lalonde, Y Durocher - Journal of biotechnology, 2017 - Elsevier
Over the last years, the biopharmaceutical industry has significantly turned its biologics
production towards mammalian cell expression systems. The presence of glycosylation …
production towards mammalian cell expression systems. The presence of glycosylation …
The art of CHO cell engineering: A comprehensive retrospect and future perspectives
Chinese hamster ovary (CHO) cells represent the most frequently applied host cell system
for industrial manufacturing of recombinant protein therapeutics. CHO cells are capable of …
for industrial manufacturing of recombinant protein therapeutics. CHO cells are capable of …
RNA interference functions as an antiviral immunity mechanism in mammals
Diverse eukaryotic hosts produce virus-derived small interfering RNAs (siRNAs) to direct
antiviral immunity by RNA interference (RNAi). However, it remains unknown whether the …
antiviral immunity by RNA interference (RNAi). However, it remains unknown whether the …
The emerging CHO systems biology era: harnessing the 'omics revolution for biotechnology
HF Kildegaard, D Baycin-Hizal, NE Lewis… - Current opinion in …, 2013 - Elsevier
Chinese hamster ovary (CHO) cells are the primary factories for biopharmaceuticals
because of their capacity to correctly fold and post-translationally modify recombinant …
because of their capacity to correctly fold and post-translationally modify recombinant …
An'omics approach towards CHO cell engineering
P Datta, RJ Linhardt… - Biotechnology and …, 2013 - Wiley Online Library
Chinese hamster ovarian cells (CHO) cells have been extensively utilized for industrial
production of biopharmaceutical products, such as monoclonal antibodies, human growth …
production of biopharmaceutical products, such as monoclonal antibodies, human growth …
Use of a small molecule cell cycle inhibitor to control cell growth and improve specific productivity and product quality of recombinant proteins in CHO cell cultures
Z Du, D Treiber, JD McCarter… - Biotechnology and …, 2015 - Wiley Online Library
The continued need to improve therapeutic recombinant protein productivity has led to
ongoing assessment of appropriate strategies in the biopharmaceutical industry to establish …
ongoing assessment of appropriate strategies in the biopharmaceutical industry to establish …
Engineering CHO cell growth and recombinant protein productivity by overexpression of miR-7
N Barron, N Kumar, N Sanchez, P Doolan… - Journal of …, 2011 - Elsevier
The efficient production of recombinant proteins by Chinese Hamster Ovary (CHO) cells in
modern bioprocesses is often augmented by the use of proliferation control strategies. The …
modern bioprocesses is often augmented by the use of proliferation control strategies. The …
Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencing
The pyrosequencing technology from 454 Life Sciences and a novel assembly approach for
cDNA sequences with the Newbler Assembler were used to achieve a major step forward to …
cDNA sequences with the Newbler Assembler were used to achieve a major step forward to …
[HTML][HTML] Next-generation sequencing of the Chinese hamster ovary microRNA transcriptome: Identification, annotation and profiling of microRNAs as targets for …
Chinese hamster ovary (CHO) cells are the predominant cell factory for the production of
recombinant therapeutic proteins. Nevertheless, the lack in publicly available sequence …
recombinant therapeutic proteins. Nevertheless, the lack in publicly available sequence …
[HTML][HTML] CHO microRNA engineering is growing up: Recent successes and future challenges
Abstract microRNAs with their ability to regulate complex pathways that control cellular
behavior and phenotype have been proposed as potential targets for cell engineering in the …
behavior and phenotype have been proposed as potential targets for cell engineering in the …