ER-phagy (reticulophagy) defines the degradation of portions of the endoplasmic reticulum
(ER) within lysosomes or vacuoles. It is part of the self-digestion (ie, autophagic) programs …

The endoplasmic reticulum (ER) is a large, dynamic structure that serves many roles in the
cell including calcium storage, protein synthesis and lipid metabolism. The diverse functions …

Close appositions between the membrane of the endoplasmic reticulum (ER) and other
intracellular membranes have important functions in cell physiology. These include lipid …

The large GTP ase dynamin is the first protein shown to catalyze membrane fission.
Dynamin and its related proteins are essential to many cell functions, from endocytosis to …

Hereditary spastic paraplegia (HSP) is a rare neurodegenerative disorder with the
predominant clinical manifestation of spasticity in the lower extremities. HSP is categorised …

In addition to commonly associated environmental factors, genomic factors may cause
cerebral palsy. We performed whole-exome sequencing of 250 parent–offspring trios, and …

INTRODUCTION The endoplasmic reticulum (ER) is a continuous, membrane-bound
organelle, spanning from the nuclear envelope to the outer cell periphery, that contacts and …

Mitochondria are highly dynamic organelles that undergo frequent fusion and fission. Optic
atrophy 1 (OPA1) is an essential GTPase protein for both mitochondrial inner membrane …

The endoplasmic reticulum (ER) consists of the nuclear envelope and both peripheral ER
sheets and a peripheral tubular network [1, 2]. In response to physiological or pathological …

Dynamin, the founding member of a family of dynamin-like proteins (DLPs) implicated in
membrane remodelling, has a critical role in endocytic membrane fission events. The use of …