DNA sequencing to detect residual disease in adults with acute myeloid leukemia prior to hematopoietic cell transplant

LW Dillon, G Gui, KM Page, N Ravindra, ZC Wong… - Jama, 2023 - jamanetwork.com
Importance Preventing relapse for adults with acute myeloid leukemia (AML) in first
remission is the most common indication for allogeneic hematopoietic cell transplant. The …

FLT3-inhibitor therapy for prevention and treatment of relapse after allogeneic hematopoietic cell transplantation

F Biavasco, R Zeiser - International Journal of Hematology, 2022 - Springer
The curative potential of allogeneic hematopoietic cell transplantation (allo-HCT) for acute
myeloid leukemia (AML) relies on the graft-versus-leukemia (GVL)-effect. Relapse after allo …

Test then erase? Current status and future opportunities for Measurable Residual Disease testing in Acute Myeloid Leukemia

AL Blackmon, CS Hourigan - Acta haematologica, 2024 - karger.com
Background: Measurable residual disease (MRD) test positivity during and after treatment in
patients with acute myeloid leukemia (AML) has been associated with higher rates of …

FLT3-ITD Measurable Residual Disease Monitoring in Acute Myeloid Leukemia Using Next-Generation Sequencing

JM Lee, S Park, I Hwang, D Kang, BS Cho, HJ Kim… - Cancers, 2022 - mdpi.com
Simple Summary FLT3-ITD monitoring is essential in AML management, and there is a great
need for sensitive monitoring methods. We present a simple and easily applicable ITD …

Understanding differential technologies for detection of MRD and how to incorporate into clinical practice

J Cloos, LL Ngai, M Heuser - Hematology, 2023 - ashpublications.org
Patient-and leukemia-specific factors assessed at diagnosis classify patients with acute
myeloid leukemia (AML) in risk categories that are prognostic for outcome. The induction …

[HTML][HTML] MRD-directed and risk-adapted individualized stratified treatment of AML

Y Zhao, H Guo, Y Chang - Chinese Journal of Cancer Research, 2023 - ncbi.nlm.nih.gov
Measurable residual disease (MRD) has been widely recognized as a biomarker for deeply
evaluating complete remission (CR), predicting relapse, guiding pre-emptive interventions …

Measurable residual disease in patients undergoing allogeneic transplant for acute myeloid leukemia

ZC Wong, LW Dillon, CS Hourigan - Best Practice & Research Clinical …, 2023 - Elsevier
The most common indication for allogeneic hematopoietic cell transplant (alloHCT) is
maintenance of remission after initial treatment for patients with acute myeloid leukemia …

Sorafenib maintenance after hematopoietic stem cell transplantation improves outcome of FLT3–ITD-mutated acute myeloid leukemia

S Aydin, R Passera, M Scaldaferri… - International Journal of …, 2022 - Springer
In a retrospective analysis, 21 acute myeloid leukemia patients receiving single-agent
sorafenib maintenance therapy in complete remission (CR) after hematopoietic stem cell …

Overcoming relapse: prophylactic or pre-emptive use of azacitidine or FLT3 inhibitors after allogeneic transplantation for AML or MDS

Y Najima - International Journal of Hematology, 2023 - Springer
Relapse remains the most critical obstacle in treatment by allogeneic hematopoietic stem
cell transplantation (HSCT). Non-relapse mortality has improved annually, but relapse …

[HTML][HTML] CLONAL DYNAMICS AND RELAPSE RISK REVEALED BY HIGH SENSITIVITY FLT3-ITD DETECTION IN ACUTE MYELOID LEUKEMIA

KA Oduro Jr, T Spivey, EM Moore, H Meyerson… - Modern Pathology, 2024 - Elsevier
The ability to detect low level disease is key to our understanding of clonal heterogeneity in
acute myeloid leukemia (AML) and residual disease that elude conventional assays and …