DNA sequencing to detect residual disease in adults with acute myeloid leukemia prior to hematopoietic cell transplant
Importance Preventing relapse for adults with acute myeloid leukemia (AML) in first
remission is the most common indication for allogeneic hematopoietic cell transplant. The …
remission is the most common indication for allogeneic hematopoietic cell transplant. The …
FLT3-inhibitor therapy for prevention and treatment of relapse after allogeneic hematopoietic cell transplantation
F Biavasco, R Zeiser - International Journal of Hematology, 2022 - Springer
The curative potential of allogeneic hematopoietic cell transplantation (allo-HCT) for acute
myeloid leukemia (AML) relies on the graft-versus-leukemia (GVL)-effect. Relapse after allo …
myeloid leukemia (AML) relies on the graft-versus-leukemia (GVL)-effect. Relapse after allo …
Test then erase? Current status and future opportunities for Measurable Residual Disease testing in Acute Myeloid Leukemia
AL Blackmon, CS Hourigan - Acta haematologica, 2024 - karger.com
Background: Measurable residual disease (MRD) test positivity during and after treatment in
patients with acute myeloid leukemia (AML) has been associated with higher rates of …
patients with acute myeloid leukemia (AML) has been associated with higher rates of …
FLT3-ITD Measurable Residual Disease Monitoring in Acute Myeloid Leukemia Using Next-Generation Sequencing
JM Lee, S Park, I Hwang, D Kang, BS Cho, HJ Kim… - Cancers, 2022 - mdpi.com
Simple Summary FLT3-ITD monitoring is essential in AML management, and there is a great
need for sensitive monitoring methods. We present a simple and easily applicable ITD …
need for sensitive monitoring methods. We present a simple and easily applicable ITD …
Understanding differential technologies for detection of MRD and how to incorporate into clinical practice
J Cloos, LL Ngai, M Heuser - Hematology, 2023 - ashpublications.org
Patient-and leukemia-specific factors assessed at diagnosis classify patients with acute
myeloid leukemia (AML) in risk categories that are prognostic for outcome. The induction …
myeloid leukemia (AML) in risk categories that are prognostic for outcome. The induction …
[HTML][HTML] MRD-directed and risk-adapted individualized stratified treatment of AML
Y Zhao, H Guo, Y Chang - Chinese Journal of Cancer Research, 2023 - ncbi.nlm.nih.gov
Measurable residual disease (MRD) has been widely recognized as a biomarker for deeply
evaluating complete remission (CR), predicting relapse, guiding pre-emptive interventions …
evaluating complete remission (CR), predicting relapse, guiding pre-emptive interventions …
Measurable residual disease in patients undergoing allogeneic transplant for acute myeloid leukemia
The most common indication for allogeneic hematopoietic cell transplant (alloHCT) is
maintenance of remission after initial treatment for patients with acute myeloid leukemia …
maintenance of remission after initial treatment for patients with acute myeloid leukemia …
Sorafenib maintenance after hematopoietic stem cell transplantation improves outcome of FLT3–ITD-mutated acute myeloid leukemia
In a retrospective analysis, 21 acute myeloid leukemia patients receiving single-agent
sorafenib maintenance therapy in complete remission (CR) after hematopoietic stem cell …
sorafenib maintenance therapy in complete remission (CR) after hematopoietic stem cell …
Overcoming relapse: prophylactic or pre-emptive use of azacitidine or FLT3 inhibitors after allogeneic transplantation for AML or MDS
Y Najima - International Journal of Hematology, 2023 - Springer
Relapse remains the most critical obstacle in treatment by allogeneic hematopoietic stem
cell transplantation (HSCT). Non-relapse mortality has improved annually, but relapse …
cell transplantation (HSCT). Non-relapse mortality has improved annually, but relapse …
[HTML][HTML] CLONAL DYNAMICS AND RELAPSE RISK REVEALED BY HIGH SENSITIVITY FLT3-ITD DETECTION IN ACUTE MYELOID LEUKEMIA
KA Oduro Jr, T Spivey, EM Moore, H Meyerson… - Modern Pathology, 2024 - Elsevier
The ability to detect low level disease is key to our understanding of clonal heterogeneity in
acute myeloid leukemia (AML) and residual disease that elude conventional assays and …
acute myeloid leukemia (AML) and residual disease that elude conventional assays and …