Background: The study of tinnitus mechanisms has increased tenfold in the last decade. The
common denominator for all of these studies is the goal of elucidating the underlying neural …

In the auditory cortex, synaptic inhibition is known to be involved in shaping receptive fields,
enhancing temporal precision, and regulating gain. Cortical inhibition is provided by local …

Highlights•The responses of neurons in the auditory cortex (AC) to complex sounds cannot
be predicted based on their responses to tones.•AC tone-evoked responses are shaped by …

Excitation is balanced by inhibition to cortical neurons across a wide range of conditions. To
understand how this relationship is maintained, we broadly suppressed the activity of …

Background Understanding speech in the presence of background noise often becomes
increasingly difficult with age. These age-related speech processing deficits reflect …

An organism's ability to detect and discriminate sensory inputs depends on the recent
stimulus history. For example, perceptual detection thresholds for a brief tone can be …

Auditory neurons are often described in terms of their spectrotemporal receptive fields
(STRFs). These map the relationship between features of the sound spectrogram and firing …

Sound discrimination is essential in many species for communicating and foraging. Bats, for
example, use sounds for echolocation and communication. In the bat auditory cortex there …

Acoustic processing requires integration over time. We have used in vivo intracellular
recording to measure neuronal integration times in anesthetized rats. Using natural sounds …

Recent studies have demonstrated the high selectivity of neurons in primary auditory cortex
(A1) and a highly sparse representation of sounds by the population of A1 neurons in awake …