The impact of tobacco chemicals and nicotine on placental development

MA Suter, KM Aagaard - Prenatal diagnosis, 2020 - Wiley Online Library
Despite decades of messages warning about the dangers of tobacco use in pregnancy, 10%
to 15% of pregnant women continue to smoke. Furthermore, an increased popularity of …

Early abnormal placentation and evidence of vascular endothelial growth factor system dysregulation at the feto-maternal interface after periconceptional alcohol …

GS Gualdoni, PV Jacobo, C Barril… - Frontiers in …, 2022 - frontiersin.org
Adequate placentation, placental tissue remodeling and vascularization is essential for the
success of gestation and optimal fetal growth. Recently, it was suggested that abnormal …

Prenatal alcohol exposure is associated with changes in placental gene co-expression networks

MA Deyssenroth, RP Williams, C Lesseur… - Scientific reports, 2024 - nature.com
Alcohol consumption during pregnancy can result in a range of adverse postnatal outcomes
among exposed children. However, identifying at-risk children is challenging given the …

Effects of early daily alcohol exposure on placental function and fetal growth in a rhesus macaque model

JO Lo, MC Schabel, VHJ Roberts, TK Morgan… - American journal of …, 2022 - Elsevier
Background Prenatal alcohol exposure is the most common cause of birth defects and
intellectual disabilities and can increase the risk of stillbirth and negatively impact fetal …

An interaction between fetal sex and placental weight and efficiency predicts intrauterine growth in response to maternal protein insufficiency and gestational …

STC Kwan, BH Presswood, KK Helfrich… - Biology of sex …, 2020 - Springer
Background Individuals exposed to gestational stressors such as alcohol exhibit a spectrum
of growth patterns, suggesting individualized responses to the stressors. We hypothesized …

Perigestational alcohol consumption induces altered early placentation and organogenic embryo growth restriction by disruption of trophoblast angiogenic factors

GS Gualdoni, MR Ventureira, TA Coll… - Reproductive …, 2021 - Elsevier
Research question Maternal alcohol consumption produces fetal retardation and
malformations, probably associated with placental defects. Does perigestational alcohol …

The association between prenatal alcohol exposure and protein expression in human placenta

BD Holbrook, S Davies, S Cano, S Shrestha… - Birth defects …, 2019 - Wiley Online Library
Background The need for earlier recognition of children at risk for neurobehavioral problems
associated with prenatal ethanol exposure (PAE) has prompted investigations of biomarkers …

Fetal alcohol spectrum disorder: embryogenesis under reduced retinoic acid signaling conditions

A Fainsod, L Bendelac-Kapon, Y Shabtai - … III: Vitamin A and Retinoic Acid …, 2020 - Springer
Abstract Fetal Alcohol Spectrum Disorder (FASD) is a complex set of developmental
malformations, neurobehavioral anomalies and mental disabilities induced by exposing …

Involvement of metalloproteinase and nitric oxide synthase/nitric oxide mechanisms in early decidual angiogenesis–vascularization of normal and experimental …

GS Gualdoni, C Barril, PV Jacobo… - Frontiers in Cell and …, 2023 - frontiersin.org
Successful pregnancy for optimal fetal growth requires adequate early angiogenesis and
remodeling of decidual spiral arterioles during placentation. Prior to the initiation of invasion …

Abnormal growth and morphogenesis of placenta at term is linked to adverse fetal development after perigestational alcohol consumption up to early gestation in …

GS Gualdoni, L Pérez‐Tito, C Barril… - Birth Defects …, 2022 - Wiley Online Library
Background Gestation alcohol consumption produces fetal growth restriction and
malformations by affecting the embryo–fetal development. Recently a relationship between …