Brain health is the humans' primary goal in achieving health and longevity. Brainstem
glioma (BSG) has a high disability and mortality rate, posing a serious threat to children's …

Primary malignant brain tumors are the most common solid neoplasm in childhood. Despite
recent advances, many children affected by aggressive or metastatic brain tumors still …

Temozolomide (TMZ), as the first-line chemotherapeutic agent, relies on inducing DNA
methylation of O 6-guanine for treating glioma. However, the survival time of patients are …

Cisplatin (cis) is a first-line chemotherapeutic used for the treatment of intractable pediatric
brainstem glioma (PBSG). Its therapeutic effect in PBSG is, however, critically challenged by …

The blood–brain barrier (BBB) continues to be one of the main clinical obstacles in the
treatment of glioma. Current chemotherapies always bring many different side effects, some …

Background: Gliomas are the most malignant tumors of the nervous system. Even though
their survival outcome is closely affected by immune-related genes (IRGs) in the tumor …

Diffuse intrinsic pontine glioma (DIPG) is a highly malignant brain tumor that mainly occurs
in children with extremely low overall survival. Traditional therapeutic strategies, such as …

Simple Summary Diffuse midline glioma (DMG) is a highly aggressive brain tumor primarily
affecting children and young adults. It grows diffusely in midline structures. Unfortunately …

Pediatric high-grade gliomas are a devastating subset of brain tumors, characterized by their
aggressive pathophysiology and limited treatment options. Among them, H3 K27-altered …

In recent years, the continuous development of innovative nanopharmaceuticals is
expanding their biomedical and clinical applications. Nanomedicines are being …