Structure-activity relationship (SAR) study and design strategies of nitrogen-containing heterocyclic moieties for their anticancer activities

J Akhtar, AA Khan, Z Ali, R Haider, MS Yar - European journal of medicinal …, 2017 - Elsevier
The present review article offers a detailed account of the design strategies employed for the
synthesis of nitrogen-containing anticancer agents. The results of different studies describe …

Ferrocene-containing hybrids as potential anticancer agents: Current developments, mechanisms of action and structure-activity relationships

R Wang, H Chen, W Yan, M Zheng, T Zhang… - European Journal of …, 2020 - Elsevier
Cancer is one of the most fatal threatens to human health throughout the world. The major
challenges in the control and eradication of cancers are the continuous emergency of drug …

Pyridazine based scaffolds as privileged structures in anti-cancer therapy

MY Jaballah, RT Serya, K Abouzid - Drug Research, 2017 - thieme-connect.com
Pyridazines, their oxo derivatives; pyridazinone as well as fused bi-or tricyclic pyridazine
containing scaffolds are key structural features of many biologically active compounds with …

Recent advances in the chemistry of pyridazine—an important representative of six-membered nitrogen heterocycles

PG Sergeev, VG Nenajdenko - Russian Chemical Reviews, 2020 - iopscience.iop.org
The review is devoted to recent advances in the chemistry of pyridazine—a six-membered
heterocycle containing two nitrogen atoms in adjacent positions. The practical significance …

[HTML][HTML] Synthesis and Antiproliferative Effect of New Alkyne-Tethered Vindoline Hybrids Containing Pharmacophoric Fragments

E Ferenczi, P Keglevich, BA Tayeb, R Minorics… - International Journal of …, 2024 - mdpi.com
In the frame of our diversity-oriented research on multitarget small molecule anticancer
agents, utilizing convergent synthetic sequences terminated by Sonogashira coupling …

CuAAC-Based Synthesis, Copper-Catalyzed Aldehyde-Forming Hydrolytic Fission and Antiproliferative Evaluation of Novel Ferrocenoylamino-Substituted Triazole …

A Dembo, E Ferenczi, T Jernei, A Bor, Z Schelz, I Zupkó… - Molecules, 2024 - mdpi.com
A series of novel triazole-tethered ferrocenoylamino-substituted cinchona–chalcone hybrids
along with two representative benzoylamino-substituted reference compounds were …

Synthesis of novel racemic 3, 4-dihydroferroceno [c] pyridines via the Ritter reaction

YS Rozhkova, IV Plekhanova, AA Gorbunov… - Tetrahedron …, 2019 - Elsevier
A new approach for the synthesis of functionalized racemic 3, 4-dihydroferroceno [c]
pyridines via the Ritter reaction of 2-methyl-1-ferrocenylpropan-1-ol with nitriles in the …

Biological evaluation of water soluble arene Ru (II) enantiomers with amino-oxime ligands

I de la Cueva-Alique, S Sierra, L Muñoz-Moreno… - Journal of Inorganic …, 2018 - Elsevier
New water soluble, enantiopure arene ruthenium compound S Ru S N-(1R, 4S)-[(η 6-p-
cymene) Ru {ĸNH (Bn), ĸNOH} Cl] Cl (Bn= benzyl, 1a′) has been synthesized. The novel …

N-ferrocenylpyridazinones and new organic analogues: Synthesis, cyclic voltammetry, DFT analysis and in vitro antiproliferative activity associated with ROS …

T Jernei, S Bősze, R Szabó, F Hudecz, K Majrik… - Tetrahedron, 2017 - Elsevier
Employing an optimized Pd-catalyzed cross-coupling reaction promoted by CuI, novel N-
ferrocenylpyridazinones along with N-phenyl-and N-(2-pyridyl) analogues were synthesized …

Synthesis of Ferrocene Tethered Heteroaromatic Compounds Using Solid Supported Reaction Method, their Cytotoxic Evaluation and Fluorescence Behavior.

S Dewangan, S Mishra, S Mawatwal… - …, 2019 - Wiley Online Library
Synthesis of ferrocene conjugated heterocyclic molecular systems involving three different
heterocyclic moieties like indole, quinoline and pyrazine was carried out in high yields using …