The regulation of cilium assembly and disassembly in development and disease
L Wang, BD Dynlacht - Development, 2018 - journals.biologists.com
The primary cilium is an antenna-like organelle assembled on most types of quiescent and
differentiated mammalian cells. This immotile structure is essential for interpreting …
differentiated mammalian cells. This immotile structure is essential for interpreting …
MAP4K3/GLK in autoimmune disease, cancer and aging
HC Chuang, TH Tan - Journal of Biomedical Science, 2019 - Springer
Abstract MAP4K3 (also named GLK) is a serine/threonine kinase, which belongs to the
mammalian Ste20-like kinase family. At 22 years of age, GLK was initially cloned and …
mammalian Ste20-like kinase family. At 22 years of age, GLK was initially cloned and …
A CCRK and a MAK kinase modulate cilia branching and length via regulation of axonemal microtubule dynamics in Caenorhabditis elegans
AK Maurya, T Rogers, P Sengupta - Current Biology, 2019 - cell.com
The diverse morphologies of primary cilia are tightly regulated as a function of cell type and
cellular state. CCRK-and MAK-related kinases have been implicated in ciliary length control …
cellular state. CCRK-and MAK-related kinases have been implicated in ciliary length control …
Insights on UNC‐104‐dynein/dynactin interactions and their implications on axonal transport in Caenorhabditis elegans
CW Chen, YF Peng, YC Yen, P Bhan… - Journal of …, 2019 - Wiley Online Library
Bidirectional cargo transport in neurons can be explained by two models: the “tug‐of‐war
model” for short‐range transport, in which several kinesin and dynein motors are bound to …
model” for short‐range transport, in which several kinesin and dynein motors are bound to …
Heterogeneity of radial spokes structural components and associated enzymes in Tetrahymena cilia
M Bicka, C Black, A Ghanaeian, E Joachimiak… - bioRxiv, 2023 - biorxiv.org
Radial spokes (RS), the T-shaped, multiprotein complexes of motile cilia, transmit regulatory
signals from the central apparatus to the outer doublet complexes including inner dynein …
signals from the central apparatus to the outer doublet complexes including inner dynein …
PTP-3 phosphatase promotes intramolecular folding of SYD-2 to inactivate kinesin-3 UNC-104 in neurons
MS Muniesh, SN Barmaver, HY Huang… - Molecular Biology of …, 2020 - Am Soc Cell Biol
UNC-104 is the Caenorhabditis elegans homolog of kinesin-3 KIF1A known for its fast
shuffling of synaptic vesicle protein transport vesicles in axons. SYD-2 is the homolog of …
shuffling of synaptic vesicle protein transport vesicles in axons. SYD-2 is the homolog of …
Methods to Quantify and Relate Axonal Transport Defects to Changes in C. elegans Behavior
SN Barmaver, M Muthaiyan Shanmugam… - … Transport: Methods and …, 2022 - Springer
Neuronal growth, differentiation, homeostasis, viability, and injury response heavily rely on
functional axonal transport (AT). Erroneous and disturbed AT may lead to accumulation of …
functional axonal transport (AT). Erroneous and disturbed AT may lead to accumulation of …
Polycystin-2 (TRPP2) regulates primary cilium length in LLC-PK1 renal epithelial cells
N Scarinci, PL Perez, HF Cantiello… - Frontiers in …, 2022 - frontiersin.org
Polycystin-2 (PC2, TRPP2) is a Ca2+ permeable nonselective cation channel whose
dysfunction generates autosomal dominant polycystic kidney disease (ADPKD). PC2 is …
dysfunction generates autosomal dominant polycystic kidney disease (ADPKD). PC2 is …
PTP-3 (LAR PTPR) promotes intramolecular folding of SYD-2 (liprin-α) to inactivate UNC-104 (KIF1A) in neurons
MM Shanmugam, SN Barmaver, HY Huang, OI Wagner - bioRxiv, 2019 - biorxiv.org
This study aims to demonstrate how PTP-3 regulates SYD-2 to control UNC-104-mediated
axonal transport. UNC-104 is the C. elegans homolog of kinesin-3 KIF-1A known for its fast …
axonal transport. UNC-104 is the C. elegans homolog of kinesin-3 KIF-1A known for its fast …