Cognitive impairment in schizophrenia: aetiology, pathophysiology, and treatment
RA McCutcheon, RSE Keefe, PK McGuire - Molecular psychiatry, 2023 - nature.com
Cognitive deficits are a core feature of schizophrenia, account for much of the impaired
functioning associated with the disorder and are not responsive to existing treatments. In this …
functioning associated with the disorder and are not responsive to existing treatments. In this …
Schizophrenia—an overview
RA McCutcheon, TR Marques, OD Howes - JAMA psychiatry, 2020 - jamanetwork.com
Importance Schizophrenia is a common, severe mental illness that most clinicians will
encounter regularly during their practice. This report provides an overview of the clinical …
encounter regularly during their practice. This report provides an overview of the clinical …
Dopamine and glutamate in schizophrenia: biology, symptoms and treatment
RA McCutcheon, JH Krystal, OD Howes - World Psychiatry, 2020 - Wiley Online Library
Glutamate and dopamine systems play distinct roles in terms of neuronal signalling, yet both
have been proposed to contribute significantly to the pathophysiology of schizophrenia. In …
have been proposed to contribute significantly to the pathophysiology of schizophrenia. In …
[HTML][HTML] Schizophrenia, dopamine and the striatum: from biology to symptoms
RA McCutcheon, A Abi-Dargham, OD Howes - Trends in neurosciences, 2019 - cell.com
The mesolimbic hypothesis has been a central dogma of schizophrenia for decades,
positing that aberrant functioning of midbrain dopamine projections to limbic regions causes …
positing that aberrant functioning of midbrain dopamine projections to limbic regions causes …
Economics and mental health: the current scenario
Economics and mental health are intertwined. Apart from the accumulating evidence of the
huge economic impacts of mental ill‐health, and the growing recognition of the effects that …
huge economic impacts of mental ill‐health, and the growing recognition of the effects that …
[HTML][HTML] Brain default-mode network dysfunction in addiction
R Zhang, ND Volkow - Neuroimage, 2019 - Elsevier
Aberrant patterns of brain functional connectivity in the default mode network (DMN) have
been observed across different classes of substance use disorder (SUD) and are associated …
been observed across different classes of substance use disorder (SUD) and are associated …
Opposite effects of dopamine and serotonin on resting-state networks: review and implications for psychiatric disorders
B Conio, M Martino, P Magioncalda, A Escelsior… - Molecular …, 2020 - nature.com
Alterations in brain intrinsic activity—as organized in resting-state networks (RSNs) such as
sensorimotor network (SMN), salience network (SN), and default-mode network (DMN) …
sensorimotor network (SMN), salience network (SN), and default-mode network (DMN) …
Psychedelic therapy in the treatment of addiction: the past, present and future
Psychedelic therapy has witnessed a resurgence in interest in the last decade from the
scientific and medical communities with evidence now building for its safety and efficacy in …
scientific and medical communities with evidence now building for its safety and efficacy in …
Glutamate and microglia activation as a driver of dendritic apoptosis: a core pathophysiological mechanism to understand schizophrenia
E Parellada, P Gassó - Translational psychiatry, 2021 - nature.com
Schizophrenia disorder remains an unsolved puzzle. However, the integration of recent
findings from genetics, molecular biology, neuroimaging, animal models and translational …
findings from genetics, molecular biology, neuroimaging, animal models and translational …
Integrative brain network and salience models of psychopathology and cognitive dysfunction in schizophrenia
Brain network models of cognitive control are central to advancing our understanding of
psychopathology and cognitive dysfunction in schizophrenia. This review examines the role …
psychopathology and cognitive dysfunction in schizophrenia. This review examines the role …