Cognitive impairment in schizophrenia: aetiology, pathophysiology, and treatment

RA McCutcheon, RSE Keefe, PK McGuire - Molecular psychiatry, 2023 - nature.com
Cognitive deficits are a core feature of schizophrenia, account for much of the impaired
functioning associated with the disorder and are not responsive to existing treatments. In this …

Schizophrenia—an overview

RA McCutcheon, TR Marques, OD Howes - JAMA psychiatry, 2020 - jamanetwork.com
Importance Schizophrenia is a common, severe mental illness that most clinicians will
encounter regularly during their practice. This report provides an overview of the clinical …

Dopamine and glutamate in schizophrenia: biology, symptoms and treatment

RA McCutcheon, JH Krystal, OD Howes - World Psychiatry, 2020 - Wiley Online Library
Glutamate and dopamine systems play distinct roles in terms of neuronal signalling, yet both
have been proposed to contribute significantly to the pathophysiology of schizophrenia. In …

[HTML][HTML] Schizophrenia, dopamine and the striatum: from biology to symptoms

RA McCutcheon, A Abi-Dargham, OD Howes - Trends in neurosciences, 2019 - cell.com
The mesolimbic hypothesis has been a central dogma of schizophrenia for decades,
positing that aberrant functioning of midbrain dopamine projections to limbic regions causes …

Economics and mental health: the current scenario

M Knapp, G Wong - World Psychiatry, 2020 - Wiley Online Library
Economics and mental health are intertwined. Apart from the accumulating evidence of the
huge economic impacts of mental ill‐health, and the growing recognition of the effects that …

[HTML][HTML] Brain default-mode network dysfunction in addiction

R Zhang, ND Volkow - Neuroimage, 2019 - Elsevier
Aberrant patterns of brain functional connectivity in the default mode network (DMN) have
been observed across different classes of substance use disorder (SUD) and are associated …

Opposite effects of dopamine and serotonin on resting-state networks: review and implications for psychiatric disorders

B Conio, M Martino, P Magioncalda, A Escelsior… - Molecular …, 2020 - nature.com
Alterations in brain intrinsic activity—as organized in resting-state networks (RSNs) such as
sensorimotor network (SMN), salience network (SN), and default-mode network (DMN) …

Psychedelic therapy in the treatment of addiction: the past, present and future

R Zafar, M Siegel, R Harding, T Barba… - Frontiers in …, 2023 - frontiersin.org
Psychedelic therapy has witnessed a resurgence in interest in the last decade from the
scientific and medical communities with evidence now building for its safety and efficacy in …

Glutamate and microglia activation as a driver of dendritic apoptosis: a core pathophysiological mechanism to understand schizophrenia

E Parellada, P Gassó - Translational psychiatry, 2021 - nature.com
Schizophrenia disorder remains an unsolved puzzle. However, the integration of recent
findings from genetics, molecular biology, neuroimaging, animal models and translational …

Integrative brain network and salience models of psychopathology and cognitive dysfunction in schizophrenia

V Menon, L Palaniyappan, K Supekar - Biological Psychiatry, 2023 - Elsevier
Brain network models of cognitive control are central to advancing our understanding of
psychopathology and cognitive dysfunction in schizophrenia. This review examines the role …