Growing evidence suggests an unusual epidemiologic association between cancer and
certain neurological conditions, particularly age-related neurodegenerative diseases …

Rho GTPases are molecular switches that elicit distinct effects on the actomyosin
cytoskeleton to accurately promote cytokinesis. Although they represent less than 1% of the …

Coordinate control of different classes of cyclins is fundamentally important for cell cycle
regulation and tumor suppression, yet the underlying mechanisms are incompletely …

Correct orientation of cell division is considered an important factor for the achievement of
normal brain size, as mutations in genes that affect this process are among the leading …

Primary microcephaly is a neurodevelopmental disorder that is caused by a reduction in
brain size as a result of defects in the proliferation of neural progenitor cells during …

Epidemiologic data suggest that people who develop neurodegenerative diseases of aging
have a decreased risk of cancer. This is intriguing, since there is growing evidence that …

It has been hypothesized that oncogenesis and neurodegeneration may share common
mechanistic foundations. Recent evidence now reveals a number of genes in which …

Mutations in citron (CIT), leading to loss or inactivation of the citron kinase protein (CITK),
cause primary microcephaly in humans and rodents, associated with cytokinesis failure and …

Binge alcohol exposure in adolescent rats potently inhibits adult hippocampal neurogenesis
by altering neural progenitor cell (NPC) proliferation and survival; however, it is not clear …

Autosomal recessive primary microcephaly (MCPH) is a static neurodevelopmental disorder
characterized by congenital small head circumference and non-progressive intellectual …