Alzheimer's disease (AD) predominantly occurs as a late onset (LOAD) form involving
neurodegeneration and cognitive decline with progressive memory loss. Risk factors that …

Alzheimer's Disease (AD) contributes to most cases of dementia. Its prominent
neuropathological features are the extracellular neuritic plaques and intercellular …

The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …

Cellular senescence is a state of terminal cell cycle arrest associated with various
macromolecular changes and a hypersecretory phenotype. In the brain, senescent cells …

Importance Factors associated with synapse loss beyond amyloid-β plaques and
neurofibrillary tangles may more closely correlate with the emergence of cognitive deficits in …

Alzheimer´ s disease (AD) stands out as the most common chronic neurodegenerative
disorder. AD is characterized by progressive cognitive decline and memory loss, with …

The clinical definition of neurodegenerative diseases is based on symptoms that reflect
terminal damage of specific brain regions. This is misleading as it tells little about the initial …

Cellular senescence, a state of irreversible cell-cycle arrest caused by a variety of cellular
stresses, is critically involved in age-related tissue dysfunction in various organs. However …

Microglial activation occurs early in Alzheimer's disease (AD) and previous studies reported
both detrimental and protective effects of microglia on AD progression. Here, we used CSF …

Objective To investigate molecular biomarkers of a‐synuclein and tau aggregation,
autophagy, and inflammation in the saliva of de novo Parkinson's disease (PD) patients in …