[HTML][HTML] Carrier-free nanodrugs with efficient drug delivery and release for cancer therapy: From intrinsic physicochemical properties to external modification
The considerable development of carrier-free nanodrugs has been achieved due to their
high drug-loading capability, simple preparation method, and offering “all-in-one” functional …
high drug-loading capability, simple preparation method, and offering “all-in-one” functional …
Nanoparticle formulations of cisplatin for cancer therapy
The genotoxic agent cisplatin, used alone or in combination with radiation and/or other
chemotherapeutic agents, is an important first‐line chemotherapy for a broad range of …
chemotherapeutic agents, is an important first‐line chemotherapy for a broad range of …
Hyaluronic acid-targeted and pH-responsive drug delivery system based on metal-organic frameworks for efficient antitumor therapy
Q Sun, H Bi, Z Wang, C Li, X Wang, J Xu, H Zhu… - Biomaterials, 2019 - Elsevier
Drug delivery systems (DDSs) have emerged to help delivering the required cargo into the
region of the tumor, achieving the objectives of extenuating the potential damage to the body …
region of the tumor, achieving the objectives of extenuating the potential damage to the body …
A native drug-free macromolecular therapeutic to trigger mutual reinforcing of endoplasmic reticulum stress and mitochondrial dysfunction for cancer treatment
Drug-free macromolecular therapeutics are promising alternatives to traditional drugs.
Nanomedicines with multiple organelles targeting can potentially increase the efficacy …
Nanomedicines with multiple organelles targeting can potentially increase the efficacy …
Carbon quantum dots with intrinsic mitochondrial targeting ability for mitochondria-based theranostics
We prepare for the first time a novel type of fluorescent carbon quantum dot (or carbon dot,
CD) with intrinsic mitochondrial targeting ability by a one-step hydrothermal treatment of …
CD) with intrinsic mitochondrial targeting ability by a one-step hydrothermal treatment of …
Mitochondrial-targeting anticancer agent conjugates and nanocarrier systems for cancer treatment
G Battogtokh, YY Cho, JY Lee, HS Lee… - Frontiers in …, 2018 - frontiersin.org
The mitochondrion is an important intracellular organelle for drug targeting due to its key
roles and functions in cellular proliferation and death. In the last few decades, several …
roles and functions in cellular proliferation and death. In the last few decades, several …
Tumor-and mitochondria-targeted nanoparticles eradicate drug resistant lung cancer through mitochondrial pathway of apoptosis
H Wang, F Zhang, H Wen, W Shi, Q Huang… - Journal of …, 2020 - Springer
Chemotherapeutic drugs frequently encounter multidrug resistance. ATP from mitochondria
helps overexpression of drug efflux pumps to induce multidrug resistance, so mitochondrial …
helps overexpression of drug efflux pumps to induce multidrug resistance, so mitochondrial …
Future of nanotherapeutics: Targeting the cellular sub-organelles
Many diseases originate from alterations at nanoscale levels. Precise drug delivery should
be achieved not only at cell level, but also at organelle level to achieve maximum …
be achieved not only at cell level, but also at organelle level to achieve maximum …
Mitochondria-targeting polydopamine nanoparticles to deliver doxorubicin for overcoming drug resistance
Mitochondria play a critical role in diverse cellular processes, such as energy production
and apoptosis regulation. The mitochondria-targeted drug delivery is becoming a potential …
and apoptosis regulation. The mitochondria-targeted drug delivery is becoming a potential …
Two‐dimensional nanomaterials for cancer nanotheranostics
Emerging nanotechnologies show unprecedented advantages in accelerating cancer
theranostics. Among them, two‐dimensional nanomaterials (2DNMs) represent a novel type …
theranostics. Among them, two‐dimensional nanomaterials (2DNMs) represent a novel type …