As the importance of cell heterogeneity has begun to be emphasized, single-cell
sequencing approaches are rapidly adopted to study cell heterogeneity and cellular …

Developmental hematopoiesis consists of multiple, partially overlapping hematopoietic
waves that generate the differentiated blood cells required for embryonic development while …

Life-long reconstitution of a tissue's resident stem cell compartment with engrafted cells has
the potential to durably replenish organ function. Here, we demonstrate the engraftment of …

We surveyed 16 published and unpublished data sets to determine whether a consistent
pattern of transcriptional deregulation in aging murine hematopoietic stem cells (HSC) …

Durable reconstitution of the distal lung epithelium with pluripotent stem cell (PSC)
derivatives, if realized, would represent a promising therapy for diseases that result from …

The human hematopoietic stem cell harbors remarkable regenerative potential that can be
harnessed therapeutically. During early development, hematopoietic stem cells in the fetal …

The journey of a hematopoietic stem cell (HSC) involves the passage through successive
anatomical sites where HSCs are in direct contact with their surrounding microenvironment …

Hematopoietic differentiation of human pluripotent stem cells (hPSCs) requires orchestration
of dynamic cell and gene regulatory networks but often generates blood cells that lack …

The haematopoietic system is a classical stem cell hierarchy that maintains all the blood
cells in the body. Haematopoietic stem cells (HSCs) are rare, highly potent cells that reside …

Human pluripotent stem cell differentiation towards hematopoietic progenitor cell can serve
as an in vitro model for human embryonic hematopoiesis, but the dynamic change of …