▪ Abstract The Class 2 α-helical cytokines consist of interleukin-10 (IL-10), IL-19, IL-20, IL-22,
IL-24 (Mda-7), and IL-26, interferons (IFN-α,-β,-ε,-κ,-ω,-δ,-τ, and-γ) and interferon-like …

The “holy grail” of cancer therapy is to identify and exploit genetic elements and signal
transduction pathways capable of selectively destroying tumor cells without eliciting harmful …

Both PI3K/AKT/mTOR/S6K1 and mitogen activated protein kinase (MAPK) signaling
cascades play an important role in cell proliferation, survival, angiogenesis, and metastasis …

Human X‐box binding protein‐1 (XBP1) is an alternatively spliced transcription factor that
participates in the unfolded protein response (UPR), a stress‐signaling pathway that allows …

This review focuses on primary cultures of human prostatic epithelial cells and their
applications as models of normal and malignant biological behavior. Current abilities to …

Background & Objective: Breast cancer is the most common cancer in women and is the
leading cause of death from cancer among women. The purpose of this study was to …

“Differentiation therapy” provides a unique and potentially effective, less toxic treatment
paradigm for cancer. Moreover, combining “differentiation therapy” with molecular …

An obstacle to effective gene-based cancer therapies is the limited number of cancer-
specific growth suppressing and apoptosis-inducing genes. Using a differentiation induction …

This study was carried out to evaluate the anticancer effects of guava leaf extracts and its
fractions. The chemical compositions of the active extracts were also determined. In the …

Apoptosis and autophagy play seminal roles in maintaining organ homeostasis. Apoptosis
represents canonical type I programmed cell death. Autophagy is viewed as pro-survival …