Abstract The 2020 Nobel Prize in Chemistry was awarded to Emmanuelle Charpentier and
Jennifer Doudna for the development of the Clustered regularly interspaced short …

Zebrafish (Danio rerio) is a valuable non-mammalian vertebrate model widely used to study
development and disease, including more recently cancer. The evolutionary conservation of …

The interactions of nanomedicines with biological environments is heavily influenced by
their physicochemical properties. Formulation design and optimization are therefore key …

Different molecular subtypes of glioblastoma (GBM) have been recently identified, of which
the mesenchymal subtype is associated with worst prognoses. Here, we report that …

Intracellular reactive sulfur species and reactive oxygen species play vital roles in
immunologic mechanism. As an emerging signal transmitter, SO 2 can be generated as the …

Zebrafish represent a vertebrate model organism that has been widely, and increasingly,
employed over the last decade in the study of developmental processes, wound healing …

Introduction: Patients with metastatic cancer suffer the highest rate of cancer-related death,
but existing animal models of metastasis have disadvantages that limit our ability to …

The molecular underpinnings of aggressive breast cancers remain mainly obscure. Here we
demonstrate that activation of the transcription factor c-Myb is required for the prometastatic …

Ovo-like transcriptional repressor 1 (OVOL1) is a key mediator of epithelial lineage
determination and mesenchymal–epithelial transition (MET). The cytokines transforming …

It is well established that transforming growth factor-β (TGFβ) switches its function from being
a tumor suppressor to a tumor promoter during the course of tumorigenesis, which involves …