Collateral damage: insulin-dependent diabetes induced with checkpoint inhibitors

AM Stamatouli, Z Quandt, AL Perdigoto, PL Clark… - Diabetes, 2018 - Am Diabetes Assoc
Insulin-dependent diabetes may occur in patients with cancers who are treated with
checkpoint inhibitors (CPIs). We reviewed cases occurring over a 6-year period at two …

Primary immunodeficiency and autoimmunity: a comprehensive review

L Amaya-Uribe, M Rojas, G Azizi, JM Anaya… - Journal of …, 2019 - Elsevier
The primary immunodeficiency diseases (PIDs) include many genetic disorders that affect
different components of the innate and adaptive responses. The number of distinct genetic …

Immune disorders in Hashimoto's thyroiditis: what do we know so far?

A Pyzik, E Grywalska… - Journal of …, 2015 - Wiley Online Library
This review of literature attempts to identify the factors that are involved in the pathogenesis
of Hashimoto thyroiditis, an immune defect in an individual with genetic susceptibility …

Current understanding of CTLA-4: from mechanism to autoimmune diseases

MM Hossen, Y Ma, Z Yin, Y Xia, J Du… - Frontiers in …, 2023 - frontiersin.org
Autoimmune diseases (ADs) are characterized by the production of autoreactive
lymphocytes, immune responses to self-antigens, and inflammation in related tissues and …

What makes a good genetic association study?

AT Hattersley, MI McCarthy - the Lancet, 2005 - thelancet.com
Genetic association studies are central to efforts to identify and characterise genomic
variants underlying susceptibility to multifactorial disease. However, obtaining robust …

Targeting cytotoxic T‐lymphocyte antigen‐4 (CTLA‐4) A novel strategy for the treatment of melanoma and other malignancies

SJ O'Day, O Hamid, WJ Urba - … International Journal of the …, 2007 - Wiley Online Library
Cancer immunotherapy centers on modulating the host's tumor‐directed immune response.
One promising approach involves augmentation of cell‐mediated immunity by interrupting T …

Celiac disease and autoimmune thyroid disease

CL Ch'ng, MK Jones, JGC Kingham - Clinical medicine & …, 2007 - Marshfield Clinic
Celiac disease (CD) or gluten sensitive enteropathy is relatively common in western
populations with prevalence around 1%. With the recent availability of sensitive and specific …

The emerging toxicity profiles of anti–CTLA-4 antibodies across clinical indications

AM Di Giacomo, M Biagioli, M Maio - Seminars in oncology, 2010 - Elsevier
The promising new class of immunomodulating antibodies directed against cytotoxic T-
lymphocyte antigen-4 (CTLA-4) has been extensively tested in clinical trials and found to be …

Immunogenetics of Hashimoto's thyroiditis

DA Chistiakov - Journal of autoimmune diseases, 2005 - Springer
Hashimoto's thyroiditis (HT) is an organ-specific T-cell mediated disease. It is a complex
disease, with a strong genetic component. To date, significant progress has been made …

Immune checkpoint molecules in reproductive immunology

E Miko, M Meggyes, K Doba, A Barakonyi… - Frontiers in …, 2019 - frontiersin.org
Immune checkpoint molecules, like CTLA-4, TIM-3, PD-1, are negative regulators of immune
responses to avoid immune injury. Checkpoint regulators are thought to actively participate …