The Drosophila Mushroom Body: From Architecture to Algorithm in a Learning Circuit

MN Modi, Y Shuai, GC Turner - Annual review of neuroscience, 2020 - annualreviews.org
The Drosophila brain contains a relatively simple circuit for forming Pavlovian associations,
yet it achieves many operations common across memory systems. Recent advances have …

[HTML][HTML] A model for basic emotions using observations of behavior in Drosophila

S Gu, F Wang, NP Patel, JA Bourgeois… - Frontiers in …, 2019 - frontiersin.org
Emotion plays a crucial role, both in general human experience and in psychiatric illnesses.
Despite the importance of emotion, the relative lack of objective methodologies to …

The connectome of an insect brain

M Winding, BD Pedigo, CL Barnes, HG Patsolic, Y Park… - Science, 2023 - science.org
Brains contain networks of interconnected neurons and so knowing the network architecture
is essential for understanding brain function. We therefore mapped the synaptic-resolution …

The connectome of the adult Drosophila mushroom body provides insights into function

F Li, JW Lindsey, EC Marin, N Otto, M Dreher… - Elife, 2020 - elifesciences.org
Making inferences about the computations performed by neuronal circuits from synapse-
level connectivity maps is an emerging opportunity in neuroscience. The mushroom body …

[PDF][PDF] A genetically encoded fluorescent sensor enables rapid and specific detection of dopamine in flies, fish, and mice

F Sun, J Zeng, M Jing, J Zhou, J Feng, SF Owen, Y Luo… - Cell, 2018 - cell.com
Dopamine (DA) is a central monoamine neurotransmitter involved in many physiological
and pathological processes. A longstanding yet largely unmet goal is to measure DA …

[PDF][PDF] A complete electron microscopy volume of the brain of adult Drosophila melanogaster

Z Zheng, JS Lauritzen, E Perlman, CG Robinson… - Cell, 2018 - cell.com
Drosophila melanogaster has a rich repertoire of innate and learned behaviors. Its 100,000-
neuron brain is a large but tractable target for comprehensive neural circuit mapping. Only …

Multisensory learning binds neurons into a cross-modal memory engram

Z Okray, PF Jacob, C Stern, K Desmond, N Otto… - Nature, 2023 - nature.com
Associating multiple sensory cues with objects and experience is a fundamental brain
process that improves object recognition and memory performance. However, neural …

The neuronal architecture of the mushroom body provides a logic for associative learning

Y Aso, D Hattori, Y Yu, RM Johnston, NA Iyer, TTB Ngo… - elife, 2014 - elifesciences.org
We identified the neurons comprising the Drosophila mushroom body (MB), an associative
center in invertebrate brains, and provide a comprehensive map describing their potential …

A connectome of a learning and memory center in the adult Drosophila brain

S Takemura, Y Aso, T Hige, A Wong, Z Lu, CS Xu… - Elife, 2017 - elifesciences.org
Understanding memory formation, storage and retrieval requires knowledge of the
underlying neuronal circuits. In Drosophila, the mushroom body (MB) is the major site of …

Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila

Y Aso, D Sitaraman, T Ichinose, KR Kaun, K Vogt… - elife, 2014 - elifesciences.org
Animals discriminate stimuli, learn their predictive value and use this knowledge to modify
their behavior. In Drosophila, the mushroom body (MB) plays a key role in these processes …