Lipid nanoparticles (LNPs) are currently the most promising clinical nucleic acids drug
delivery vehicles. LNPs prevent the degradation of cargo nucleic acids during blood …

With the rapid development of biopharmaceuticals and the outbreak of COVID-19, the world
has ushered in a frenzy to develop gene therapy. Therefore, therapeutic genes have …

Cancer is the second most frequent cause of death worldwide, with 28.4 million new cases
expected for 2040. Despite de advances in the treatment, it remains a challenge because of …

The burden of cancer is increasing globally. Several challenges facing its mainstream
treatment approaches have formed the basis for the development of targeted delivery …

Glioblastoma is the most aggressive form of brain tumor, accounting for the highest mortality
and morbidity rates. Current treatment for patients with glioblastoma includes maximal safe …

Chitosan (CS), a biocompatible and biodegradable polymer produced from chitin, has
attracted interest in drug delivery due to its unique properties and diverse applications. Over …

Nanoscale drug delivery systems (nDDS) have been employed widely in enhancing the
therapeutic efficacy of drugs against diseases with reduced side effects. Although several …

Transcription factors (TFs) control numerous genes that are directly relevant to many human
disorders. However, developing specific reagents targeting TFs within intact cells is …

The use of biomaterials in delivering CRISPR/Cas9 for gene therapy in infectious diseases
holds tremendous potential. This innovative approach combines the advantages of …

How to effectively transform the pro-oncogenic tumor microenvironments (TME) surrounding
a tumor into an anti-tumoral never fails to attract people to study. Small interfering RNA …