Lipid nanoparticles optimized for targeting and release of nucleic acid
Y Jia, X Wang, L Li, F Li, J Zhang… - Advanced Materials, 2024 - Wiley Online Library
Lipid nanoparticles (LNPs) are currently the most promising clinical nucleic acids drug
delivery vehicles. LNPs prevent the degradation of cargo nucleic acids during blood …
delivery vehicles. LNPs prevent the degradation of cargo nucleic acids during blood …
Mechanisms and challenges of nanocarriers as non-viral vectors of therapeutic genes for enhanced pulmonary delivery
H Wang, L Qin, X Zhang, J Guan, S Mao - Journal of Controlled Release, 2022 - Elsevier
With the rapid development of biopharmaceuticals and the outbreak of COVID-19, the world
has ushered in a frenzy to develop gene therapy. Therefore, therapeutic genes have …
has ushered in a frenzy to develop gene therapy. Therefore, therapeutic genes have …
Targeted liposomes: A nonviral gene delivery system for cancer therapy
MT Luiz, JAP Dutra, LB Tofani, JTC de Araújo… - Pharmaceutics, 2022 - mdpi.com
Cancer is the second most frequent cause of death worldwide, with 28.4 million new cases
expected for 2040. Despite de advances in the treatment, it remains a challenge because of …
expected for 2040. Despite de advances in the treatment, it remains a challenge because of …
Technological advances in the use of viral and non-viral vectors for delivering genetic and non-genetic cargos for cancer therapy
DM Dogbey, VES Torres, E Fajemisin… - Drug Delivery and …, 2023 - Springer
The burden of cancer is increasing globally. Several challenges facing its mainstream
treatment approaches have formed the basis for the development of targeted delivery …
treatment approaches have formed the basis for the development of targeted delivery …
Nanomedicine for glioblastoma: Progress and future prospects
Glioblastoma is the most aggressive form of brain tumor, accounting for the highest mortality
and morbidity rates. Current treatment for patients with glioblastoma includes maximal safe …
and morbidity rates. Current treatment for patients with glioblastoma includes maximal safe …
Advances in chitosan-based drug delivery systems: A comprehensive review for therapeutic applications
Chitosan (CS), a biocompatible and biodegradable polymer produced from chitin, has
attracted interest in drug delivery due to its unique properties and diverse applications. Over …
attracted interest in drug delivery due to its unique properties and diverse applications. Over …
[HTML][HTML] Recent advances in zwitterionic nanoscale drug delivery systems to overcome biological barriers
Nanoscale drug delivery systems (nDDS) have been employed widely in enhancing the
therapeutic efficacy of drugs against diseases with reduced side effects. Although several …
therapeutic efficacy of drugs against diseases with reduced side effects. Although several …
Evolution of nanobodies specific for BCL11A
Transcription factors (TFs) control numerous genes that are directly relevant to many human
disorders. However, developing specific reagents targeting TFs within intact cells is …
disorders. However, developing specific reagents targeting TFs within intact cells is …
Biomaterials-mediated CRISPR/Cas9 delivery: recent challenges and opportunities in gene therapy
AK Dubey, E Mostafavi - Frontiers in Chemistry, 2023 - frontiersin.org
The use of biomaterials in delivering CRISPR/Cas9 for gene therapy in infectious diseases
holds tremendous potential. This innovative approach combines the advantages of …
holds tremendous potential. This innovative approach combines the advantages of …
[HTML][HTML] Remodeling the tumor immune microenvironment via siRNA therapy for precision cancer treatment
L Jiang, Y Qi, L Yang, YB Miao, W Ren, H Liu… - Asian Journal of …, 2023 - Elsevier
How to effectively transform the pro-oncogenic tumor microenvironments (TME) surrounding
a tumor into an anti-tumoral never fails to attract people to study. Small interfering RNA …
a tumor into an anti-tumoral never fails to attract people to study. Small interfering RNA …