Abstract tRNAs are key partners in ribosome-dependent protein synthesis. This process is
highly dependent on the fidelity of tRNA aminoacylation by aminoacyl-tRNA synthetases …

The study of eukaryotic tRNA processing has given rise to an explosion of new information
and insights in the last several years. We now have unprecedented knowledge of each step …

Protein crystallization was discovered by chance about 150 years ago and was developed
in the late 19th century as a powerful purification tool and as a demonstration of chemical …

Transfer RNAs (tRNAs) are central players in translation, functioning as adapter molecules
between the informational level of nucleic acids and the functional level of proteins. They …

Posttranscriptional modifications of transfer RNAs (tRNAs) are critical for all core aspects of
tRNA function, such as folding, stability, and decoding. Most tRNA modifications were …

Eukaryotic transfer RNA (tRNA) precursors undergo sequential processing steps to become
mature tRNAs. In humans, ELAC2 carries out 3′ end processing of both nucleus-encoded …

Summary tRNA function is based on unique structures that enable mRNA decoding using
anticodon trinucleotides. These structures interact with specific aminoacyl-tRNA synthetases …

Human mitochondrial transcripts contain messenger and ribosomal RNAs flanked by
transfer RNAs (tRNAs), which are excised by mitochondrial RNase (mtRNase) P and Z to …

Following synthesis, tRNAs are peppered by numerous chemical modifications which may
differentially affect a tRNA's structure and function. Although modifications affecting the …

Faithful translation of mRNA into the corresponding polypeptide is a complex multistep
process, requiring accurate amino acid selection, transfer RNA (tRNA) charging and mRNA …