Cell responses to the extracellular matrix depend on specific signaling events. These are
important from early development, through differentiation and tissue homeostasis, immune …

The extracellular matrix critically controls cancer cell behavior by inducing several signaling
pathways through cell membrane receptors. Besides conferring structural properties to …

Recurrent breast cancer presents significant challenges with aggressive phenotypes and
treatment resistance. Therefore, novel therapeutics are urgently needed. Here, we report …

The action of the collagen binding receptor tyrosine kinase (RTK) discoidin domain receptor
2 (DDR2) in both tumor and tumor stromal cells has been established as critical for breast …

Biomechanical changes in the tumor microenvironment influence tumor progression and
metastases. Collagen content and fiber organization within the tumor stroma are major …

Increased collagen deposition by breast cancer (BC)-associated mesenchymal
stem/multipotent stromal cells (MSC) promotes metastasis, but the mechanisms are …

Gene regulatory network perturbations contribute to the development and progression of
cancer, however, molecular determinants that mediate transcriptional perturbations remain a …

Summary Discoidin domain receptor 1 (DDR1) is a tyrosine kinase collagen adhesion
receptor that mediates cell migration through association with non-muscle myosin IIA …

High levels of collagen deposition in human and mouse breast tumors are associated with
poor outcome due to increased local invasion and distant metastases. Using a genetic …

Discoidin domain receptors (DDR), including DDR1 and DDR2, are special types of the
transmembrane receptor tyrosine kinase superfamily. DDR are activated by binding to the …