The neuroprotective effects of fisetin, a natural flavonoid in neurodegenerative diseases: Focus on the role of oxidative stress

SS Hassan, S Samanta, R Dash… - Frontiers in …, 2022 - frontiersin.org
Oxidative stress (OS) disrupts the chemical integrity of macromolecules and increases the
risk of neurodegenerative diseases. Fisetin is a flavonoid that exhibits potent antioxidant …

Effect of methylmercury on fetal neurobehavioral development: an overview of the possible mechanisms of toxicity and the neuroprotective effect of phytochemicals

G Bjørklund, H Antonyak, A Polishchuk… - Archives of …, 2022 - Springer
Methylmercury (MeHg) is a global environmental pollutant with neurotoxic effects. Exposure
to MeHg via consumption of seafood and fish can severely impact fetal neurobehavioral …

The Neuroprotective Role of Fisetin in Different Neurological Diseases: A Systematic Review

Y Jiang, X Tang, P Deng, C Jiang, Y He, D Hao… - Molecular …, 2023 - Springer
Neurological diseases place a substantial burden on public health and have a serious
impact on the quality of life of patients. Despite the multifaceted pathological process …

Gestational fisetin exerts neuroprotection by regulating mitochondria-directed canonical Wnt signaling, BBB integrity, and apoptosis in prenatal VPA-induced rodent …

S Mehra, AU Ahsan, M Sharma, M Budhwar… - Molecular …, 2024 - Springer
Embryonic valproic acid (VPA) has been considered a potential risk factor for autism.
Majority of studies indicated that targeting autism-associated alterations in VPA-induced …

Mechanisms of oxidative stress in methylmercury-induced neurodevelopmental toxicity

X Li, J Pan, Y Wei, L Ni, B Xu, Y Deng, T Yang, W Liu - Neurotoxicology, 2021 - Elsevier
Methylmercury (MeHg) is a long-lasting organic environmental pollutant that poses a great
threat to human health. Ingestion of seafood containing MeHg is the most important way by …

Placental senescence pathophysiology is shared between peripartum cardiomyopathy and preeclampsia in mouse and human

JD Roh, C Castro, A Yu, S Rana, S Shahul… - Science Translational …, 2024 - science.org
Peripartum cardiomyopathy (PPCM) is an idiopathic form of pregnancy-induced heart failure
associated with preeclampsia. Circulating factors in late pregnancy are thought to contribute …

Medicinal plants and natural products can play a significant role in mitigation of mercury toxicity

S Bhattacharya - Interdisciplinary Toxicology, 2018 - sciendo.com
Mercury is a heavy metal of considerable toxicity. Scientific literature reveals various plants
and plant derived natural products, ie, phytochemicals, which can alleviate experimentally …

An Overview of Recent Advances in the Neuroprotective Potentials of Fisetin against Diverse Insults in Neurological Diseases and the Underlying Signaling Pathways

X Tang, P Deng, Y Jiang, L Zhang, Y He, H Yang - Biomedicines, 2023 - mdpi.com
The nervous system plays a leading role in the regulation of physiological functions and
activities in the body. However, a variety of diseases related to the nervous system have a …

Fisetin Attenuates Paracetamol-Induced Hepatotoxicity by Regulating CYP2E1 Enzyme

RA Ugan, E Cadirci, H Un, I Cinar… - Anais da Academia …, 2023 - SciELO Brasil
Paracetamol is one of the drugs that cause hepatic damage. Fisetin has wide
pharmacological effects such as anticancer, antiinflammatory and antioxidant. We aimed to …

[HTML][HTML] Fisetin as a senotherapeutic agent: Evidence and perspectives for age-related diseases

J Tavenier, JO Nehlin, MB Houlind… - Mechanisms of Ageing …, 2024 - Elsevier
Fisetin, a flavonoid naturally occurring in plants, fruits, and vegetables, has recently gained
attention for its potential role as a senotherapeutic agent for the treatment of age-related …